Technology Process of 1-(3,5-Diiodobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline
There total 8 articles about 1-(3,5-Diiodobenzyl)-6,7-dimethoxy-2-trifluoroacetyl-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-(4-Amino-3,5-diiodobenzyl)-2-trifluoroacetyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline;
With
sulfuric acid; sodium nitrite;
In
acetic acid;
at 0 - 5 ℃;
With
hypophosphorous acid;
In
water; acetic acid;
at 0 - 20 ℃;
for 48h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 50 percent / tetrahydrofuran / Ambient temperature
2: 87 percent / H2 / 5percent Pd/C / ethyl acetate / 2 h / 3102.9 Torr
3: 44 percent / benzyltrimethylammonium dichloroiodate, CaCO3 / CH2Cl2; methanol / Ambient temperature
4: 1.) NaNO2, conc. H2SO4, gl. acetic acid, 2.) H3PO2 / 1.) 0 - 5 deg C, 2.) RT, 2 d
With
sulfuric acid; hydrogen; hypophosphorous acid; N,N,N-trimethylbenzenemethanaminium dichloroiodate; acetic acid; calcium carbonate; sodium nitrite;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm960208o
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 58 percent / toluene / 72 h / Heating
2: POCl3 / acetonitrile / 4 h / Heating
3: NaBH4 / methanol / Ambient temperature
4: 50 percent / tetrahydrofuran / Ambient temperature
5: 87 percent / H2 / 5percent Pd/C / ethyl acetate / 2 h / 3102.9 Torr
6: 44 percent / benzyltrimethylammonium dichloroiodate, CaCO3 / CH2Cl2; methanol / Ambient temperature
7: 1.) NaNO2, conc. H2SO4, gl. acetic acid, 2.) H3PO2 / 1.) 0 - 5 deg C, 2.) RT, 2 d
With
sodium tetrahydroborate; sulfuric acid; hydrogen; hypophosphorous acid; N,N,N-trimethylbenzenemethanaminium dichloroiodate; acetic acid; calcium carbonate; sodium nitrite; trichlorophosphate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; toluene; acetonitrile;
DOI:10.1021/jm960208o
