N-phthalyl-4-fluoro-4-benzyloxycarbonyl-glutamic acid, α-methyl, γ-benzyl diester

Base Information

Chemical Name:N-phthalyl-4-fluoro-4-benzyloxycarbonyl-glutamic acid, α-methyl, γ-benzyl diester
CAS No.:133384-82-4
Molecular Formula:C₂₉H₂₄FNO₈
Molecular Weight:533.51
Hs Code.:

Synonyms:N-phthalyl-4-fluoro-4-benzyloxycarbonyl-glutamic acid, α-methyl, γ-benzyl diester

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Chemical Property of N-phthalyl-4-fluoro-4-benzyloxycarbonyl-glutamic acid, α-methyl, γ-benzyl diester

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Technology Process of N-phthalyl-4-fluoro-4-benzyloxycarbonyl-glutamic acid, α-methyl, γ-benzyl diester

There total 2 articles about N-phthalyl-4-fluoro-4-benzyloxycarbonyl-glutamic acid, α-methyl, γ-benzyl diester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 26878-24-0
methyl 2-phthalimidoacrylate

: 133384-81-3
dibenzyl 2-fluoromalonate

: 133384-82-4
N-phthalyl-4-fluoro-4-benzyloxycarbonyl-glutamic acid, α-methyl, γ-benzyl diester

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.333333h;
DOI:10.1016/S0040-4020(01)80939-X

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 133384-82-4
N-phthalyl-4-fluoro-4-benzyloxycarbonyl-glutamic acid, α-methyl, γ-benzyl diester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / p-toluene sulfonic acid / toluene / Heating

2: 60 percent / NaH / tetrahydrofuran / 0.33 h / 0 °C

With sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4020(01)80939-X