5-(2,6-difluorophenyl)-3-{[1-(cyclopropylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxamide

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Chemical Name:5-(2,6-difluorophenyl)-3-{[1-(cyclopropylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxamide
CAS No.:1253734-41-6
Molecular Formula:C₂₅H₂₄F₂N₆O₃S
Molecular Weight:526.567
Hs Code.:

Synonyms:5-(2,6-difluorophenyl)-3-{[1-(cyclopropylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxamide

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Chemical Property of 5-(2,6-difluorophenyl)-3-{[1-(cyclopropylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxamide

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Technology Process of 5-(2,6-difluorophenyl)-3-{[1-(cyclopropylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxamide

There total 9 articles about 5-(2,6-difluorophenyl)-3-{[1-(cyclopropylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1253734-38-1
5-(2,6-difluorophenyl)-3-{[1-(cyclopropylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carbonitrile

: 1253734-41-6
5-(2,6-difluorophenyl)-3-{[1-(cyclopropylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxamide

Guidance literature:: With sodium hydroxide; In ethanol; for 0.5h; Reflux;

Reference yield:

: 1253733-68-4
3-(4-iodophenyl)-1H-pyrazol-4-ylamine

: 1253734-41-6
5-(2,6-difluorophenyl)-3-{[1-(cyclopropylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: pyridine / dichloromethane / 3 h / 0 - 20 °C

2.1: phosphorus pentoxide / 23 h / 165 °C / Inert atmosphere

3.1: 0.17 h / Inert atmosphere

3.2: 1.5 h / 130 °C

4.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C

5.1: potassium hydroxide; bromine / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

7.1: 1,4-dioxane / 0.17 h / Inert atmosphere

7.2: 2 h / 120 °C

8.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

9.1: sodium hydroxide / ethanol / 0.5 h / Reflux

With pyridine; phosphorus pentoxide; bromine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1253733-69-5
2,6-difluoro-N-[5-(4-iodophenyl)-1H-pyrazol-4-yl]benzamide

: 1253734-41-6
5-(2,6-difluorophenyl)-3-{[1-(cyclopropylsulphonyl)piperidin-4-yl]amino}-1H-pyrazolo[4,3-c]isoquinoline-7-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: phosphorus pentoxide / 23 h / 165 °C / Inert atmosphere

2.1: 0.17 h / Inert atmosphere

2.2: 1.5 h / 130 °C

3.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C

4.1: potassium hydroxide; bromine / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

6.1: 1,4-dioxane / 0.17 h / Inert atmosphere

6.2: 2 h / 120 °C

7.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

8.1: sodium hydroxide / ethanol / 0.5 h / Reflux

With phosphorus pentoxide; bromine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;