4-(2-chloro-6,7-dimethoxy-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-(2-chloro-6,7-dimethoxy-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester
• CAS No.: 205259-50-3
• Molecular Formula: C₁₉H₂₅ClN₄O₄
• Molecular Weight: 408.885
• Mol file: 205259-50-3.mol

Synonyms:4-(2-chloro-6,7-dimethoxy-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester

Chemical Property of 4-(2-chloro-6,7-dimethoxy-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-chloro-6,7-dimethoxy-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester

There total 1 articles about 4-(2-chloro-6,7-dimethoxy-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-chloro-6,7-dimethoxy-3H-quinazolin-4-one (27631-29-4) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 4-(2-chloro-6,7-dimethoxy-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester (205259-50-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/S0960-894X(03)00634-6

Reference yield:

4-(2-chloro-6,7-dimethoxy-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester (205259-50-3) → 4-(2-chloro-6,7-dimethoxy-quinazolin-4-yl)-piperazine-1-carboxylic acid (4-phenoxy-phenyl)-amide

Guidance literature:

Multi-step reaction with 2 steps

1: CF₃COOH / CH₂Cl₂ / 1.5 h / cooling

2: Et₃N / dimethylformamide / 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm020505v

Reference yield:

4-(2-chloro-6,7-dimethoxy-4-quinazolinyl)-1-piperazinecarboxylic acid tert-butyl ester (205259-50-3) → 4-(6,7-Dimethoxy-2-morpholino-4-quinazolinyl)-N-(4-phenoxyphenyl)-1-piperazinecarboxamide

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / 1-methyl-pyrrolidin-2-one / 3 h / 140 °C

2: CF₃COOH / CH₂Cl₂ / 1.5 h / cooling

3: Et₃N / dimethylformamide / 20 °C

With triethylamine; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm020505v

upstream raw materials:

2-chloro-6,7-dimethoxy-3H-quinazolin-4-one

1-t-Butoxycarbonylpiperazine