2-(3-Carboxymethoxy-benzyl)-2-(4,5-diphenyl-oxazol-2-yl)-pent-4-enoic acid ethyl ester

Base Information

Chemical Name:2-(3-Carboxymethoxy-benzyl)-2-(4,5-diphenyl-oxazol-2-yl)-pent-4-enoic acid ethyl ester
CAS No.:152494-98-9
Molecular Formula:C₃₁H₂₉NO₆
Molecular Weight:511.574
Hs Code.:

Synonyms:2-(3-Carboxymethoxy-benzyl)-2-(4,5-diphenyl-oxazol-2-yl)-pent-4-enoic acid ethyl ester

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Chemical Property of 2-(3-Carboxymethoxy-benzyl)-2-(4,5-diphenyl-oxazol-2-yl)-pent-4-enoic acid ethyl ester

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Technology Process of 2-(3-Carboxymethoxy-benzyl)-2-(4,5-diphenyl-oxazol-2-yl)-pent-4-enoic acid ethyl ester

There total 7 articles about 2-(3-Carboxymethoxy-benzyl)-2-(4,5-diphenyl-oxazol-2-yl)-pent-4-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 152495-13-1
ethyl α-<<3-<2-(1,1-dimethylethoxy)-2-oxoethoxy>phenyl>methyl>-4,5-diphenyl-α-(2-propenyl)-2-oxazoleacetate

: 152494-98-9
2-(3-Carboxymethoxy-benzyl)-2-(4,5-diphenyl-oxazol-2-yl)-pent-4-enoic acid ethyl ester

Guidance literature:: With trifluoroacetic acid; for 0.166667h; Ambient temperature;
DOI:10.1021/jm00076a017

Reference yield:

: 26820-93-9
ethyl 4,5-diphenyl-2-oxazoleacetate

: 152494-98-9
2-(3-Carboxymethoxy-benzyl)-2-(4,5-diphenyl-oxazol-2-yl)-pent-4-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine, p-TsOH / toluene / 18 h / Heating

2: 48 percent / H₂ / 10percent Pd/C / ethyl acetate / 1551.4 Torr

3: 72 percent / K₂CO₃, 18-crown-6 / tetrahydrofuran / 0.25 h / Ambient temperature

4: 61 percent / CF₃CO₂H / 0.17 h / Ambient temperature

With piperidine; 18-crown-6 ether; hydrogen; potassium carbonate; toluene-4-sulfonic acid; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; toluene;
DOI:10.1021/jm00076a017

Reference yield:

: 119-53-9,579-44-2
2-hydroxy-2-phenylacetophenone

: 152494-98-9
2-(3-Carboxymethoxy-benzyl)-2-(4,5-diphenyl-oxazol-2-yl)-pent-4-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) 4-(dimethylamino)pyridine, pyridine, 2.) AcOH, NH₄OAc / 1.) CH₂Cl₂, a) 10 deg C, 30 min, b) RT, 2 h, 2.) reflux, 2 h

2: piperidine, p-TsOH / toluene / 18 h / Heating

3: 48 percent / H₂ / 10percent Pd/C / ethyl acetate / 1551.4 Torr

4: 72 percent / K₂CO₃, 18-crown-6 / tetrahydrofuran / 0.25 h / Ambient temperature

5: 61 percent / CF₃CO₂H / 0.17 h / Ambient temperature

With piperidine; pyridine; dmap; 18-crown-6 ether; ammonium acetate; hydrogen; potassium carbonate; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; toluene;
DOI:10.1021/jm00076a017