C₂₈H₂₇FN₂O₅

Base Information

Chemical Name:C₂₈H₂₇FN₂O₅
CAS No.:1565779-13-6
Molecular Formula:C₂₈H₂₇FN₂O₅
Molecular Weight:490.531
Hs Code.:

C<sub>28</sub>H<sub>27</sub>FN<sub>2</sub>O<sub>5</sub>

Synonyms:C₂₈H₂₇FN₂O₅

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Chemical Property of C₂₈H₂₇FN₂O₅

Chemical Property:

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Technology Process of C₂₈H₂₇FN₂O₅

There total 11 articles about C₂₈H₂₇FN₂O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1565781-85-2
C₂₈H₂₉FN₂O₆

: 1565779-14-7
C₂₈H₂₇FN₂O₅

: 1565779-13-6
C₂₈H₂₇FN₂O₅

Guidance literature:: C₂₈H₂₉FN₂O₆; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 36h;

Reference yield:

: 847547-91-5
2-chloro-3-hydroxyquinoline-4-carboxylic acid

: 1565779-13-6
C₂₈H₂₇FN₂O₅

Guidance literature:: Multi-step reaction with 10 steps

1.1: methanol; toluene / Cooling with ice

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; ethanol; toluene / 6 h / 100 °C / Sealed tube; Inert atmosphere

3.1: diisobutylaluminium hydride / dichloromethane; toluene / 2.5 h / -78 - 20 °C

4.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1.5 h / 20 °C

5.1: tetrahydrofuran / 0 °C

6.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 20 °C

7.1: boron tribromide / dichloromethane / 1 h / 20 °C

8.1: pyrrolidine / methanol / 8 h / 100 °C / Molecular sieve; Sealed tube

9.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.75 h / 20 °C

10.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0 - 20 °C

10.2: 36 h / 20 °C

With pyrrolidine; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;

Reference yield:

: 1565779-05-6
C₁₂H₁₀ClNO₃

: 1565779-13-6
C₂₈H₂₇FN₂O₅

Guidance literature:: Multi-step reaction with 9 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; ethanol; toluene / 6 h / 100 °C / Sealed tube; Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane; toluene / 2.5 h / -78 - 20 °C

3.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1.5 h / 20 °C

4.1: tetrahydrofuran / 0 °C

5.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 20 °C

6.1: boron tribromide / dichloromethane / 1 h / 20 °C

7.1: pyrrolidine / methanol / 8 h / 100 °C / Molecular sieve; Sealed tube

8.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 0.75 h / 20 °C

9.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0 - 20 °C

9.2: 36 h / 20 °C

With pyrrolidine; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron tribromide; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;