(1aS,9aS)-3-[(4,5-dimethoxy-2-nitrophenyl)methyl] 1,5-dimethyl ester 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1a,2,3,8,9,9a-hexahydro-7-(methoxymethoxy)-1H-aziridino[2,3-c][1]benzazocine-1,3,5(2H)-tricarboxylic acid

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Chemical Name:(1aS,9aS)-3-[(4,5-dimethoxy-2-nitrophenyl)methyl] 1,5-dimethyl ester 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1a,2,3,8,9,9a-hexahydro-7-(methoxymethoxy)-1H-aziridino[2,3-c][1]benzazocine-1,3,5(2H)-tricarboxylic acid
CAS No.:192061-10-2
Molecular Formula:C₃₃H₄₅N₃O₁₃Si
Molecular Weight:719.818
Hs Code.:

(1aS,9aS)-3-[(4,5-dimethoxy-2-nitrophenyl)methyl] 1,5-dimethyl ester 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1a,2,3,8,9,9a-hexahydro-7-(methoxymethoxy)-1H-aziridino[2,3-c][1]benzazocine-1,3,5(2H)-tricarboxylic acid

Synonyms:(1aS,9aS)-3-[(4,5-dimethoxy-2-nitrophenyl)methyl] 1,5-dimethyl ester 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1a,2,3,8,9,9a-hexahydro-7-(methoxymethoxy)-1H-aziridino[2,3-c][1]benzazocine-1,3,5(2H)-tricarboxylic acid

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Chemical Property of (1aS,9aS)-3-[(4,5-dimethoxy-2-nitrophenyl)methyl] 1,5-dimethyl ester 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1a,2,3,8,9,9a-hexahydro-7-(methoxymethoxy)-1H-aziridino[2,3-c][1]benzazocine-1,3,5(2H)-tricarboxylic acid

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Technology Process of (1aS,9aS)-3-[(4,5-dimethoxy-2-nitrophenyl)methyl] 1,5-dimethyl ester 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1a,2,3,8,9,9a-hexahydro-7-(methoxymethoxy)-1H-aziridino[2,3-c][1]benzazocine-1,3,5(2H)-tricarboxylic acid

There total 11 articles about (1aS,9aS)-3-[(4,5-dimethoxy-2-nitrophenyl)methyl] 1,5-dimethyl ester 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1a,2,3,8,9,9a-hexahydro-7-(methoxymethoxy)-1H-aziridino[2,3-c][1]benzazocine-1,3,5(2H)-tricarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 42855-00-5
nitroveratryloxycarbonyl chloride

: 192061-09-9
(1aS,9aS)-dimethyl ester 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1a,2,3,8,9,9a-hexahydro-7-(methoxymethoxy)-1H-aziridino[2,3-c][1]benzazocine-1,5-dicarboxylic acid

: 192061-10-2
(1aS,9aS)-3-[(4,5-dimethoxy-2-nitrophenyl)methyl] 1,5-dimethyl ester 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1a,2,3,8,9,9a-hexahydro-7-(methoxymethoxy)-1H-aziridino[2,3-c][1]benzazocine-1,3,5(2H)-tricarboxylic acid

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 4h;
DOI:10.1016/S0040-4020(99)01046-7

Reference yield:

: 125229-14-3
methyl 3-methoxymethyloxy-4-methyl-5-nitrobenzene

: 192061-10-2
(1aS,9aS)-3-[(4,5-dimethoxy-2-nitrophenyl)methyl] 1,5-dimethyl ester 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1a,2,3,8,9,9a-hexahydro-7-(methoxymethoxy)-1H-aziridino[2,3-c][1]benzazocine-1,3,5(2H)-tricarboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / NaOMe / methanol; dimethylformamide / 3.5 h

2: 96 percent / imidazole / dimethylformamide / 24 h

3: 93 percent / DDQ; H₂O / CH₂Cl₂ / 1.5 h

4: 82 percent / Dess-Martin reagent / CH₂Cl₂ / 2.5 h

5: H₂ / Pd/C / methanol / 0.13 h

6: MgSO₄; 4A molecular sieves / CH₂Cl₂ / Heating

7: 110 mg / NaCNBH₃; TFA / CH₂Cl₂; H₂O / 0.07 h

8: 88 percent / iPr₂NEt; DMAP / CH₂Cl₂ / 4 h

With 1H-imidazole; dmap; 4 A molecular sieve; water; hydrogen; sodium methylate; sodium cyanoborohydride; magnesium sulfate; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In methanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Addition / 2: Substitution / 3: Substitution / 4: Oxidation / 5: Catalytic hydrogenation / 6: Cyclization / 7: Reduction / 8: Acylation;
DOI:10.1016/S0040-4020(99)01046-7

Reference yield:

: 192061-07-7
[2S-(2α,3α)]-methyl ester 2-[1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-[(4-methoxycarbonyl)-2-(methoxymethoxy)-6-nitrophenyl]ethyl]-3-formyl-1-aziridinecarboxylic acid

: 192061-10-2
(1aS,9aS)-3-[(4,5-dimethoxy-2-nitrophenyl)methyl] 1,5-dimethyl ester 9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1a,2,3,8,9,9a-hexahydro-7-(methoxymethoxy)-1H-aziridino[2,3-c][1]benzazocine-1,3,5(2H)-tricarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / methanol / 0.13 h

2: MgSO₄; 4A molecular sieves / CH₂Cl₂ / Heating

3: 110 mg / NaCNBH₃; TFA / CH₂Cl₂; H₂O / 0.07 h

4: 88 percent / iPr₂NEt; DMAP / CH₂Cl₂ / 4 h

With dmap; 4 A molecular sieve; hydrogen; sodium cyanoborohydride; magnesium sulfate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; water; 1: Catalytic hydrogenation / 2: Cyclization / 3: Reduction / 4: Acylation;
DOI:10.1016/S0040-4020(99)01046-7