(R)-N-(1-(4-trifluoromethylphenyl)ethyl) bis(3,5-dimethylphenyl)phosphinamide

Base Information

Chemical Name:(R)-N-(1-(4-trifluoromethylphenyl)ethyl) bis(3,5-dimethylphenyl)phosphinamide
CAS No.:721446-00-0
Molecular Formula:C₂₅H₂₇F₃NOP
Molecular Weight:445.464
Hs Code.:

Synonyms:(R)-N-(1-(4-trifluoromethylphenyl)ethyl) bis(3,5-dimethylphenyl)phosphinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-(1-(4-trifluoromethylphenyl)ethyl) bis(3,5-dimethylphenyl)phosphinamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-N-(1-(4-trifluoromethylphenyl)ethyl) bis(3,5-dimethylphenyl)phosphinamide

There total 3 articles about (R)-N-(1-(4-trifluoromethylphenyl)ethyl) bis(3,5-dimethylphenyl)phosphinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: N-(1-(4-(trifluoromethyl)phenyl)ethylidene)bis(3,5-dimethylphenyl)phosphinamide

: 721446-00-0
(R)-N-(1-(4-trifluoromethylphenyl)ethyl) bis(3,5-dimethylphenyl)phosphinamide

Guidance literature:: N-(1-(4-(trifluoromethyl)phenyl)ethylidene)bis(3,5-dimethylphenyl)phosphinamide; With tetramethyldisiloxane; tert-butyl alcohol; In toluene;

With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; sodium methylate; copper(l) chloride; In toluene; at 20 ℃; for 17h;
DOI:10.1002/anie.200353294

Reference yield:

: N-(1-(4-(trifluoromethyl)phenyl)ethylidene)bis(3,5-dimethylphenyl)phosphinamide

: (S)-N-(1-(4-trifluoromethylphenyl)ethyl) bis(3,5-dimethylphenyl)phosphinamide

: 721446-00-0
(R)-N-(1-(4-trifluoromethylphenyl)ethyl) bis(3,5-dimethylphenyl)phosphinamide

Guidance literature:: With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; tetramethyldisiloxane; copper(l) chloride; sodium methylate; In toluene; tert-butyl alcohol; at 60 ℃; for 0.5h; Title compound not separated from byproducts; microwave irradiation;
DOI:10.1139/v05-083

Reference yield:

: 74289-57-9
bis-(3,5-dimethylphenyl)chlorophosphine

: 721446-00-0
(R)-N-(1-(4-trifluoromethylphenyl)ethyl) bis(3,5-dimethylphenyl)phosphinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 26 percent / triethylamine / CH₂Cl₂; hexane / -40 - 20 °C

2.1: t-BuOH; tetramethyldisiloxane / toluene

2.2: 94 percent / CuCl; (R)-DTBM-SEGPHOS; NaOMe / toluene / 17 h / 20 °C

With tetramethyldisiloxane; triethylamine; tert-butyl alcohol; In hexane; dichloromethane; toluene;
DOI:10.1002/anie.200353294