2-((1S,2S)-2-Benzyloxy-1-ethyl-propyl)-4-(4-piperazin-1-yl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one

Base Information

Chemical Name:2-((1S,2S)-2-Benzyloxy-1-ethyl-propyl)-4-(4-piperazin-1-yl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one
CAS No.:454479-39-1
Molecular Formula:C₂₄H₃₁N₅O₂
Molecular Weight:421.542
Hs Code.:

Synonyms:2-((1S,2S)-2-Benzyloxy-1-ethyl-propyl)-4-(4-piperazin-1-yl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one

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Chemical Property of 2-((1S,2S)-2-Benzyloxy-1-ethyl-propyl)-4-(4-piperazin-1-yl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-((1S,2S)-2-Benzyloxy-1-ethyl-propyl)-4-(4-piperazin-1-yl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one

There total 1 articles about 2-((1S,2S)-2-Benzyloxy-1-ethyl-propyl)-4-(4-piperazin-1-yl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 110-85-0
piperazine

: 2-((1S,2S)-2-Benzyloxy-1-ethyl-propyl)-4-(4-bromo-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one

: 454479-39-1
2-((1S,2S)-2-Benzyloxy-1-ethyl-propyl)-4-(4-piperazin-1-yl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one

Guidance literature:: With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In toluene; at 80 ℃; for 3h;
DOI:10.1016/S0040-4039(02)00556-7

Reference yield: 51.0%

: 454479-36-8
1-[(2R,4R)-4-(4-Bromo-phenoxymethyl)-2-(2,4-difluoro-phenyl)-tetrahydro-furan-2-ylmethyl]-1H-[1,2,4]triazole

: 454479-39-1
2-((1S,2S)-2-Benzyloxy-1-ethyl-propyl)-4-(4-piperazin-1-yl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one

: 170985-86-1
4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-(benzyloxy)pentan-3-yl)-1H-1,2,4-triazol-5(4H)-one

Guidance literature:: With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In toluene; at 80 ℃; for 12h;
DOI:10.1016/S0040-4039(02)00556-7

Reference yield:

: 454479-39-1
2-((1S,2S)-2-Benzyloxy-1-ethyl-propyl)-4-(4-piperazin-1-yl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one

: 171228-49-2
posaconazote

Guidance literature:: Multi-step reaction with 2 steps

1.1: 51 percent / BINAP; t-BuONa / Pd₂(dba)3 / toluene / 12 h / 80 °C

2.1: HCOOH / Pd/C

2.2: NH₄OH / methanol / Heating

With formic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; palladium on activated charcoal; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In toluene;
DOI:10.1016/S0040-4039(02)00556-7