5'-(4,4'-dimethoxytrityl)-6-benzo[a]pyrene-1'-α-D-2'-deoxyriboside

Base Information

• Chemical Name: 5'-(4,4'-dimethoxytrityl)-6-benzo[a]pyrene-1'-α-D-2'-deoxyriboside
• CAS No.: 790710-39-3
• Molecular Formula: C₄₆H₃₈O₅
• Molecular Weight: 670.805
• Mol file: 790710-39-3.mol

Synonyms:5'-(4,4'-dimethoxytrityl)-6-benzo[a]pyrene-1'-α-D-2'-deoxyriboside

Chemical Property of 5'-(4,4'-dimethoxytrityl)-6-benzo[a]pyrene-1'-α-D-2'-deoxyriboside

Chemical Property:

Purity/Quality:

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Technology Process of 5'-(4,4'-dimethoxytrityl)-6-benzo[a]pyrene-1'-α-D-2'-deoxyriboside

There total 2 articles about 5'-(4,4'-dimethoxytrityl)-6-benzo[a]pyrene-1'-α-D-2'-deoxyriboside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 6-benzo[a]pyrene-1'-α-D-2'-deoxyriboside (667457-89-8) → 5'-(4,4'-dimethoxytrityl)-6-benzo[a]pyrene-1'-α-D-2'-deoxyriboside (790710-39-3)

Guidance literature:

With pyridine; N-ethyl-N,N-diisopropylamine; at 20 ℃; for 4h;

DOI:10.1021/ja046910o

Reference yield:

6-benzo[a]pyrene-1'-α/β-D-2'-deoxyriboside-3',5'-di(p-toluoyl) ester → 5'-(4,4'-dimethoxytrityl)-6-benzo[a]pyrene-1'-α-D-2'-deoxyriboside (790710-39-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOMe; MeOH / CH₂Cl₂ / 4 h / 20 °C

2: 73 percent / pyridine; N,N-diisopropylethylamine / 4 h / 20 °C

With pyridine; methanol; sodium methylate; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1021/ja046910o

Reference yield:

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) + 5'-(4,4'-dimethoxytrityl)-6-benzo[a]pyrene-1'-α-D-2'-deoxyriboside (790710-39-3) → 5'-(4,4'-dimethoxytrityl)-6-benzo[a]pyrene-1'-α/β-D-2'-deoxyriboside-3'-O-(cyanoethyl-N,N-diisopropylamino)phosphoramidite

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/ja046910o

upstream raw materials:

4,4'-dimethoxytrityl chloride

6-benzo[a]pyrene-1'-α-D-2'-deoxyriboside