6'-methoxy-1-(4-phenylbutyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

Base Information

Chemical Name:6'-methoxy-1-(4-phenylbutyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]
CAS No.:1070709-33-9
Molecular Formula:C₂₂H₂₉NO₂S
Molecular Weight:371.544
Hs Code.:

Synonyms:6'-methoxy-1-(4-phenylbutyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

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Chemical Property of 6'-methoxy-1-(4-phenylbutyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

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Technology Process of 6'-methoxy-1-(4-phenylbutyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

There total 8 articles about 6'-methoxy-1-(4-phenylbutyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1070709-27-1
6'-methoxy-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

: 4830-93-7
1-Chloro-4-phenylbutane

: 1070709-33-9
6'-methoxy-1-(4-phenylbutyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

Guidance literature:: With potassium carbonate; In acetonitrile; for 24h; Reflux;
DOI:10.1021/jm8007739

Reference yield:

: (E/Z)-3-bromo-2-(2-methoxyvinyl)thiophene

: 1070709-33-9
6'-methoxy-1-(4-phenylbutyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / methanol / 24 h / Heating / reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.28 - 0.3 h / -84 °C

2.2: 3 h / -84 - 20 °C

3.1: toluene-4-sulfonic acid; trimethyl orthoformate / methanol / 24 h / 20 °C

4.1: 2-Chloroethyl chloroformate / tetrahydrofuran / 0.33 h / -78 - 20 °C

4.2: 0.67 h / Heating / reflux

5.1: potassium carbonate / acetonitrile / 24 h / Heating / reflux

With n-butyllithium; potassium carbonate; toluene-4-sulfonic acid; 2-Chloroethyl chloroformate; trimethyl orthoformate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; hexane; acetonitrile;

Reference yield:

: 1070708-90-5
2-(3-bromothiophen-2-yl)acetaldehyde dimethyl acetal

: 1070709-33-9
6'-methoxy-1-(4-phenylbutyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.28 - 0.3 h / -84 °C

1.2: 3 h / -84 - 20 °C

2.1: toluene-4-sulfonic acid; trimethyl orthoformate / methanol / 24 h / 20 °C

3.1: 2-Chloroethyl chloroformate / tetrahydrofuran / 0.33 h / -78 - 20 °C

3.2: 0.67 h / Heating / reflux

4.1: potassium carbonate / acetonitrile / 24 h / Heating / reflux

With n-butyllithium; potassium carbonate; toluene-4-sulfonic acid; 2-Chloroethyl chloroformate; trimethyl orthoformate; In tetrahydrofuran; methanol; hexane; acetonitrile;