methyl (2R)-5-phenyl-3,4-dihydro-2H-pyrrole-2-carboxylate

Base Information

Chemical Name:methyl (2R)-5-phenyl-3,4-dihydro-2H-pyrrole-2-carboxylate
CAS No.:128811-50-7
Molecular Formula:C₁₂H₁₃NO₂
Molecular Weight:203.241
Hs Code.:
DSSTox Substance ID:DTXSID401152692

Synonyms:128811-50-7;DTXSID401152692;2H-Pyrrole-2-carboxylic acid, 3,4-dihydro-5-phenyl-, methyl ester, (R)-

Suppliers and Price of methyl (2R)-5-phenyl-3,4-dihydro-2H-pyrrole-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2R)-5-phenyl-3,4-dihydro-2H-pyrrole-2-carboxylate

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:203.094628657
Heavy Atom Count:15
Complexity:267

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1CCC(=N1)C2=CC=CC=C2
Isomeric SMILES:COC(=O)[C@H]1CCC(=N1)C2=CC=CC=C2

Technology Process of methyl (2R)-5-phenyl-3,4-dihydro-2H-pyrrole-2-carboxylate

There total 5 articles about methyl (2R)-5-phenyl-3,4-dihydro-2H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 128811-49-4
methyl (2R)-2-<<(tert-butyloxy)carbonyl>amino>-5-oxo-5-phenylpentanoate

: 128811-50-7
methyl (2R)-3,4-dihydro-5-phenyl-2H-pyrrole-2-carboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1002/hlca.19900730113

Reference yield:

: 6893-26-1,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
D-Glutamic acid

: 128811-50-7
methyl (2R)-3,4-dihydro-5-phenyl-2H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: H₂O / 63 h / Heating

2: SOCl₂ / 48 h / Ambient temperature; pH=0

3: 82 percent / DMAP, NEt₃ / CH₂Cl₂ / 5 h / Ambient temperature

4: 42 percent / tetrahydrofuran / 0.5 h / 0 °C

5: 89 percent / CF₃COOH / CH₂Cl₂ / 0.5 h / 0 °C

With dmap; thionyl chloride; water; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1002/hlca.19900730113

Reference yield:

: 128811-48-3
1‐(tert‐butyl) 2‐methyl (R)‐5‐oxopyrrolidine‐1,2‐dicarboxylate

: 128811-50-7
methyl (2R)-3,4-dihydro-5-phenyl-2H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 42 percent / tetrahydrofuran / 0.5 h / 0 °C

2: 89 percent / CF₃COOH / CH₂Cl₂ / 0.5 h / 0 °C

With trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1002/hlca.19900730113