3-Bromo-2-(chloromethyl)thiophene

Base Information

Chemical Name:3-Bromo-2-(chloromethyl)thiophene
CAS No.:7353-88-0
Molecular Formula:C₅H₄BrClS
Molecular Weight:211.51
Hs Code.:
European Community (EC) Number:829-087-0

Synonyms:3-bromo-2-(chloromethyl)thiophene;7353-88-0;3-bromo-2-chloromethyl-thiophene;SCHEMBL6999271;KYAGPKKOVYJXIY-UHFFFAOYSA-N;3-bromo-2-(chloromethyl)-thiophene;AKOS010150040;AT16718;EN300-55413;A1-06445

Suppliers and Price of 3-Bromo-2-(chloromethyl)thiophene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 3-Bromo-2-(chloromethyl)thiophene

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:209.89056
Heavy Atom Count:8
Complexity:78.8

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CSC(=C1Br)CCl

Technology Process of 3-Bromo-2-(chloromethyl)thiophene

There total 1 articles about 3-Bromo-2-(chloromethyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 930-96-1
3-bromo-2-thiophenecarboxaldehyde

: 7353-88-0
3-bromo-2-chloromethyl-thiophene

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 2 h / 0 °C

2: thionyl chloride / dichloromethane / 4 h / Reflux

With sodium tetrahydroborate; thionyl chloride; In methanol; dichloromethane;

Reference yield:

: 7353-88-0
3-bromo-2-chloromethyl-thiophene

: 1352041-20-3
8-((3-cyclopropyl-thiophen-2-yl)methyl)-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

1.2: 18 h

2.1: potassium phosphate / (bis(tricyclohexyl)phosphine)palladium(II) dichloride / toluene; water / 14 h / Inert atmosphere; Reflux

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 - 5 °C

4.1: 6 h / 140 °C

With potassium phosphate; sodium hydride; 3-chloro-benzenecarboperoxoic acid; (bis(tricyclohexyl)phosphine)palladium(II) dichloride; In dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 7353-88-0
3-bromo-2-chloromethyl-thiophene

: [2-(3-Bromo-thiophen-2-ylmethyl)-cyclohex-(E)-ylidene]-methyl-amine

Guidance literature:: Multi-step reaction with 3 steps

1: dioxane / 8 h / Heating

2: water / 2 h / Heating

3: 4A molecular sieves / toluene / 15 h / 50 °C

With 4 A molecular sieve; water; In 1,4-dioxane; toluene;
DOI:10.1021/jm00058a002