(1-(4-(1,3-dioxoisoindolin-2-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxylate

Base Information

Chemical Name:(1-(4-(1,3-dioxoisoindolin-2-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxylate
CAS No.:1391026-11-1
Molecular Formula:C₂₆H₂₂ClN₅O₅
Molecular Weight:519.944
Hs Code.:

Synonyms:(1-(4-(1,3-dioxoisoindolin-2-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxylate

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Chemical Property of (1-(4-(1,3-dioxoisoindolin-2-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxylate

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Technology Process of (1-(4-(1,3-dioxoisoindolin-2-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxylate

There total 3 articles about (1-(4-(1,3-dioxoisoindolin-2-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 66917-06-4
N-(4-azidobutyl)phthalimide

: 1391026-02-0
prop-2-ynyl 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxylate

: 1391026-11-1
(1-(4-(1,3-dioxoisoindolin-2-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxylate

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃;
DOI:10.1002/jhet.837

Reference yield:

: 3717-28-0
2-chloro benzaldehyde oxime

: 1391026-11-1
(1-(4-(1,3-dioxoisoindolin-2-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: chlorine / methanol / 0 - 5 °C

2.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10

2.2: 2 h / 0 - 20 °C / pH 9

3.1: water; sodium hydroxide / methanol / 1 h / pH 11 - 13 / Reflux

4.1: phosphorus pentachloride / 1 h / 45 °C

5.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

6.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C

With copper(ll) sulfate pentahydrate; phosphorus pentachloride; water; chlorine; sodium L-ascorbate; triethylamine; sodium hydroxide; In methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/jhet.837

Reference yield:

: 29568-74-9
2-chloro-N-hydroxybenzimidoyl chloride

: 1391026-11-1
(1-(4-(1,3-dioxoisoindolin-2-yl)butyl)-1H-1,2,3-triazol-4-yl)methyl 3-(2-chlorophenyl)-5-methylisoxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / methanol / 0.5 h / 0 - 5 °C / pH 10

1.2: 2 h / 0 - 20 °C / pH 9

2.1: water; sodium hydroxide / methanol / 1 h / pH 11 - 13 / Reflux

3.1: phosphorus pentachloride / 1 h / 45 °C

4.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

5.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C

With copper(ll) sulfate pentahydrate; phosphorus pentachloride; water; sodium L-ascorbate; triethylamine; sodium hydroxide; In methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1002/jhet.837