(5Z)-(9S,11S)-13-(t-butyldiphenylsiloxy)-11-fluoro-9-(tetrahydropyran-2-yloxy)-14,15,16,17,18,19,20-heptanor-5-prostenoic acid isopropyl ester

Base Information

Chemical Name:(5Z)-(9S,11S)-13-(t-butyldiphenylsiloxy)-11-fluoro-9-(tetrahydropyran-2-yloxy)-14,15,16,17,18,19,20-heptanor-5-prostenoic acid isopropyl ester
CAS No.:208114-24-3
Molecular Formula:C₃₇H₅₃FO₅Si
Molecular Weight:624.909
Hs Code.:

Synonyms:(5Z)-(9S,11S)-13-(t-butyldiphenylsiloxy)-11-fluoro-9-(tetrahydropyran-2-yloxy)-14,15,16,17,18,19,20-heptanor-5-prostenoic acid isopropyl ester

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Chemical Property of (5Z)-(9S,11S)-13-(t-butyldiphenylsiloxy)-11-fluoro-9-(tetrahydropyran-2-yloxy)-14,15,16,17,18,19,20-heptanor-5-prostenoic acid isopropyl ester

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Technology Process of (5Z)-(9S,11S)-13-(t-butyldiphenylsiloxy)-11-fluoro-9-(tetrahydropyran-2-yloxy)-14,15,16,17,18,19,20-heptanor-5-prostenoic acid isopropyl ester

There total 1 articles about (5Z)-(9S,11S)-13-(t-butyldiphenylsiloxy)-11-fluoro-9-(tetrahydropyran-2-yloxy)-14,15,16,17,18,19,20-heptanor-5-prostenoic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 208114-23-2
(5Z)-(9S,11S)-13-(t-butyldiphenylsiloxy)-11-fluoro-9-hydroxy-14,15,16,17,18,19,20-heptanor-5-prostenoic acid isopropyl ester

: 208114-24-3
(5Z)-(9S,11S)-13-(t-butyldiphenylsiloxy)-11-fluoro-9-(tetrahydropyran-2-yloxy)-14,15,16,17,18,19,20-heptanor-5-prostenoic acid isopropyl ester

Guidance literature:: With p-toluenesulfonic acid monohydrate; sodium hydrogencarbonate; In hexane; dichloromethane;

Reference yield:

: 208114-24-3
(5Z)-(9S,11S)-13-(t-butyldiphenylsiloxy)-11-fluoro-9-(tetrahydropyran-2-yloxy)-14,15,16,17,18,19,20-heptanor-5-prostenoic acid isopropyl ester

: 208114-93-6
(5Z,13E)-(9S,11S,15R)-9,15-Dihydroxy-11-fluoro-15-(2-indanyl)-16,17,18,19,20-pentanor-5,13-prostadienoic acid isopropyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: tetra-n-butylammonium fluoride

2: oxalyl chloride; dimethylsulfoxide; triethyl amine

3: sodium borohydride; cerium trichloride / methanol

4: HCl / propan-2-ol

With hydrogenchloride; sodium tetrahydroborate; cerium(III) chloride; oxalyl dichloride; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; In methanol; isopropyl alcohol; 3: Horner-Emmons condensation;

Reference yield:

: 208114-24-3
(5Z)-(9S,11S)-13-(t-butyldiphenylsiloxy)-11-fluoro-9-(tetrahydropyran-2-yloxy)-14,15,16,17,18,19,20-heptanor-5-prostenoic acid isopropyl ester

: 246246-19-5
AL-8810

Guidance literature:: Multi-step reaction with 6 steps

1: tetra-n-butylammonium fluoride

2: oxalyl chloride; dimethylsulfoxide; triethyl amine

3: sodium borohydride; cerium trichloride / methanol

4: HCl / propan-2-ol

5: lithium hydroxide / methanol

With hydrogenchloride; lithium hydroxide; sodium tetrahydroborate; cerium(III) chloride; oxalyl dichloride; tetrabutyl ammonium fluoride; dimethyl sulfoxide; triethylamine; In methanol; isopropyl alcohol; 3: Horner-Emmons condensation;