(R)-3-[4-(3-amino-benzo[d]isoxazol-6-yl)-2,6-dichloro-benzyl]-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

Base Information

Chemical Name:(R)-3-[4-(3-amino-benzo[d]isoxazol-6-yl)-2,6-dichloro-benzyl]-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one
CAS No.:956320-37-9
Molecular Formula:C₃₂H₄₄Cl₂N₄O₃Si
Molecular Weight:631.718
Hs Code.:

Synonyms:(R)-3-[4-(3-amino-benzo[d]isoxazol-6-yl)-2,6-dichloro-benzyl]-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

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Chemical Property of (R)-3-[4-(3-amino-benzo[d]isoxazol-6-yl)-2,6-dichloro-benzyl]-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

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Technology Process of (R)-3-[4-(3-amino-benzo[d]isoxazol-6-yl)-2,6-dichloro-benzyl]-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

There total 11 articles about (R)-3-[4-(3-amino-benzo[d]isoxazol-6-yl)-2,6-dichloro-benzyl]-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 956320-17-5
(R)-3',5'-dichloro-3-fluoro-4'-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-biphenyl-4-carbonitrile

: 956320-37-9
(R)-3-[4-(3-amino-benzo[d]isoxazol-6-yl)-2,6-dichloro-benzyl]-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

Guidance literature:: acetylhydroxamic acid; With potassium carbonate; In water; N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

(R)-3',5'-dichloro-3-fluoro-4'-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-biphenyl-4-carbonitrile; In water; N,N-dimethyl-formamide; at 20 - 60 ℃; for 6h;

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 956320-37-9
(R)-3-[4-(3-amino-benzo[d]isoxazol-6-yl)-2,6-dichloro-benzyl]-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid; sodium nitrite / water / 5.83 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Heating / reflux

2.2: 0.17 h / 0 - 20 °C

3.1: sodium tris(acetoxy)borohydride / 1,1-dichloroethane / 22 h / 20 - 55 °C

4.1: pyridine / dichloromethane / 12 h / 0 - 20 °C

5.1: hydrogen / palladium hydroxide on carbon / ethanol / 2 h / 20 °C / 1034.32 Torr

6.1: pyridine / dichloromethane / 2 h / 0 - 20 °C

7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 1 h / 80 °C

8.1: potassium carbonate / water; N,N-dimethyl-formamide / 0.17 h / 20 °C

8.2: 6 h / 20 - 60 °C

With pyridine; lithium aluminium tetrahydride; hydrogen; sodium tris(acetoxy)borohydride; sodium carbonate; potassium carbonate; acetic acid; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium hydroxide on carbon; In tetrahydrofuran; 1,1-dichloroethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 7.1: Suzuki Coupling;

Reference yield:

: 956320-30-2
(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-hydroxy-piperidin-1-yl)-pyrrolidin-2-one

: 956320-37-9
(R)-3-[4-(3-amino-benzo[d]isoxazol-6-yl)-2,6-dichloro-benzyl]-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane / 12 h / 0 - 20 °C

2.1: hydrogen / palladium hydroxide on carbon / ethanol / 2 h / 20 °C / 1034.32 Torr

3.1: pyridine / dichloromethane / 2 h / 0 - 20 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 1 h / 80 °C

5.1: potassium carbonate / water; N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 6 h / 20 - 60 °C

With pyridine; hydrogen; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium hydroxide on carbon; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 4.1: Suzuki Coupling;