5-bromo-N-{2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}-3-pyridinesulfonamide trifluoroacetate

Base Information

Chemical Name:5-bromo-N-{2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}-3-pyridinesulfonamide trifluoroacetate
CAS No.:1312593-28-4
Molecular Formula:C₂HF₃O₂*C₂₁H₁₈BrN₃O₃S₂
Molecular Weight:618.452
Hs Code.:

Synonyms:5-bromo-N-{2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}-3-pyridinesulfonamide trifluoroacetate

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Chemical Property of 5-bromo-N-{2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}-3-pyridinesulfonamide trifluoroacetate

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Technology Process of 5-bromo-N-{2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}-3-pyridinesulfonamide trifluoroacetate

There total 6 articles about 5-bromo-N-{2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}-3-pyridinesulfonamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312594-09-4
2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-amine

: 65001-21-0
5-bromopyridine-3-sulphonyl chloride

: 76-05-1
trifluoroacetic acid

: 1312593-28-4
5-bromo-N-{2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}-3-pyridinesulfonamide trifluoroacetate

Guidance literature:: 2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-amine; 5-bromopyridine-3-sulphonyl chloride; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 591-31-1
3-methoxy-benzaldehyde

: 1312593-28-4
5-bromo-N-{2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}-3-pyridinesulfonamide trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethyl ether; tetrahydrofuran / 3 h / Cooling with ice

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

2.2: 1 h / -78 °C

3.1: 1,1,1,3,3,3-hexamethyl-disilazane; acetic acid / 12 h / 70 °C / Inert atmosphere

4.1: sulfur; sodium hydrogencarbonate; water / tetrahydrofuran / 16 h / 35 °C

5.1: tin(IV) chloride / toluene / 0.33 h / 20 - 150 °C / microwave irradiation

5.2: 20 °C

6.1: potassium tert-butylate / N,N-dimethyl-formamide / 3 h / 20 °C

With oxalyl dichloride; potassium tert-butylate; water; tin(IV) chloride; sodium hydrogencarbonate; sulfur; acetic acid; dimethyl sulfoxide; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 37951-49-8
1-(3-methoxyphenyl)propan-1-one

: 1312593-28-4
5-bromo-N-{2,6-dimethyl-3-[3-(methyloxy)phenyl]thieno[2,3-b]pyridin-4-yl}-3-pyridinesulfonamide trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1,1,3,3,3-hexamethyl-disilazane; acetic acid / 12 h / 70 °C / Inert atmosphere

2.1: sulfur; sodium hydrogencarbonate; water / tetrahydrofuran / 16 h / 35 °C

3.1: tin(IV) chloride / toluene / 0.33 h / 20 - 150 °C / microwave irradiation

3.2: 20 °C

4.1: potassium tert-butylate / N,N-dimethyl-formamide / 3 h / 20 °C

With potassium tert-butylate; water; tin(IV) chloride; sodium hydrogencarbonate; sulfur; acetic acid; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;