isobutyl (3R)-5-benzyloxy-3-hydroxypentanoate

Base Information

Chemical Name:isobutyl (3R)-5-benzyloxy-3-hydroxypentanoate
CAS No.:912805-56-2
Molecular Formula:C₁₆H₂₄O₄
Molecular Weight:280.364
Hs Code.:

Synonyms:isobutyl (3R)-5-benzyloxy-3-hydroxypentanoate

Suppliers and Price of isobutyl (3R)-5-benzyloxy-3-hydroxypentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of isobutyl (3R)-5-benzyloxy-3-hydroxypentanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of isobutyl (3R)-5-benzyloxy-3-hydroxypentanoate

There total 2 articles about isobutyl (3R)-5-benzyloxy-3-hydroxypentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 106064-33-9
isobutyl 5-(benzyloxy)-3-oxopentanoate

: 912805-56-2
isobutyl (3R)-5-benzyloxy-3-hydroxypentanoate

Guidance literature:: With hydrogen; Ru₂Cl₂[(R)-BINAP]2*Et₃N; In methanol; at 23 ℃; for 66h; under 42923.3 Torr;
DOI:10.1021/ja062364i

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 912805-56-2
isobutyl (3R)-5-benzyloxy-3-hydroxypentanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran

1.2: 70 percent / n-BuLi

2.1: 100 percent / hydrogen / Ru₂Cl₂[(R)-BINAP]2*Et₃N / methanol / 66 h / 23 °C / 42923.3 Torr

With hydrogen; sodium hydride; Ru₂Cl₂[(R)-BINAP]2*Et₃N; In tetrahydrofuran; methanol;
DOI:10.1021/ja062364i

Reference yield:

: 912805-56-2
isobutyl (3R)-5-benzyloxy-3-hydroxypentanoate

: C₆₀H₁₁₃Cl₃O₁₂Si₅

Guidance literature:: Multi-step reaction with 11 steps

1.1: 99 percent / imidazole / dimethylformamide / 15 h / 23 °C

2.1: 93 percent / DIBAL-H / petroleum ether; toluene / 0.08 h / -78 °C

3.1: n-butyllithium; potassium tert-butoxide / petroleum ether; tetrahydrofuran / -78 - -45 °C

3.2: boron trifluoride diethyl etherate / (+)-B-methoxydiisopinocamphenylborane / petroleum ether; tetrahydrofuran; diethyl ether / -78 °C

3.3: petroleum ether; tetrahydrofuran; diethyl ether / 8.5 h

4.1: 162 mg / CH₂Cl₂; toluene / 22.5 h / -45 - 23 °C

5.1: 94 percent / hydrogen / Pd/C / methanol / 1.3 h / 23 °C

6.1: 88 percent / sodium periodate; ruthenium chloride hydrate / acetonitrile; CCl₄; H₂O / 0.5 h / 23 °C

7.1: triethylamine / toluene / 1.5 h / 23 °C

8.1: 66.2 mg / 4-(dimethylamino)pyridine / toluene / 1.5 h / 23 °C

9.1: 73 percent / hydrogen / Pd/C / methanol / 1.5 h / 23 °C

10.1: 96 percent / sodium periodate; ruthenium chloride hydrate / acetonitrile; CCl₄; H₂O / 0.83 h / 23 °C

11.1: triethylamine / toluene / 1.3 h

With 1H-imidazole; dmap; ruthenium trichloride; sodium periodate; n-butyllithium; potassium tert-butylate; hydrogen; diisobutylaluminium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; Petroleum ether; 8.1: Yamaguchi esterification;
DOI:10.1021/ja062364i