(2R,4R)-2-(Benzhydrylidene-amino)-4-phenyl-pentanoic acid benzhydryl-amide

Base Information

Chemical Name:(2R,4R)-2-(Benzhydrylidene-amino)-4-phenyl-pentanoic acid benzhydryl-amide
CAS No.:851596-37-7
Molecular Formula:C₃₇H₃₄N₂O
Molecular Weight:522.69
Hs Code.:

Synonyms:(2R,4R)-2-(Benzhydrylidene-amino)-4-phenyl-pentanoic acid benzhydryl-amide

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Chemical Property of (2R,4R)-2-(Benzhydrylidene-amino)-4-phenyl-pentanoic acid benzhydryl-amide

Chemical Property:

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Technology Process of (2R,4R)-2-(Benzhydrylidene-amino)-4-phenyl-pentanoic acid benzhydryl-amide

There total 6 articles about (2R,4R)-2-(Benzhydrylidene-amino)-4-phenyl-pentanoic acid benzhydryl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 657388-83-5
N-benzhydryl-2-(benzhydrylidene-amino)-acetamide

: ((R)-2-Iodo-1-methyl-ethyl)-benzene

: (2R,4S)-2-(Benzhydrylidene-amino)-4-phenyl-pentanoic acid benzhydryl-amide

: 851596-37-7
(2R,4R)-2-(Benzhydrylidene-amino)-4-phenyl-pentanoic acid benzhydryl-amide

: (2S,4S)-2-(Benzhydrylidene-amino)-4-phenyl-pentanoic acid benzhydryl-amide

Guidance literature:: With cesium hydroxide; N-spiro chiral quaternary ammonium bromide; In 1,3,5-trimethyl-benzene; at 0 ℃; for 2.5h;
DOI:10.1021/ja0459328

Reference yield:

: [(benzhydryl-carbamoyl)-methyl]-carbamic acid benzyl ester

: 851596-37-7
(2R,4R)-2-(Benzhydrylidene-amino)-4-phenyl-pentanoic acid benzhydryl-amide

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / ethyl acetate; methanol / 10 h / 20 °C

2: CH₂Cl₂ / 10 h / 20 °C

3: aq. CsOH; N-spiro chiral quaternary ammonium bromide / 1,3,5-trimethyl-benzene / 2.5 h / 0 °C

With cesium hydroxide; N-spiro chiral quaternary ammonium bromide; hydrogen; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; 1,3,5-trimethyl-benzene;
DOI:10.1021/ja0459328

Reference yield:

: 91-00-9
Benzhydrylamine

: 851596-37-7
(2R,4R)-2-(Benzhydrylidene-amino)-4-phenyl-pentanoic acid benzhydryl-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-methylmorpholine; ethyl chloroformate / CH₂Cl₂ / 0.5 h / 0 °C

1.2: CH₂Cl₂ / 0 - 20 °C

2.1: H₂ / Pd/C / ethyl acetate; methanol / 10 h / 20 °C

3.1: CH₂Cl₂ / 10 h / 20 °C

4.1: aq. CsOH; N-spiro chiral quaternary ammonium bromide / 1,3,5-trimethyl-benzene / 2.5 h / 0 °C

With 4-methyl-morpholine; cesium hydroxide; N-spiro chiral quaternary ammonium bromide; hydrogen; chloroformic acid ethyl ester; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; 1,3,5-trimethyl-benzene;
DOI:10.1021/ja0459328