2-[2-(2-fluoro-phenyl)-pyridin-4-yl]-6-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-pyrazol-4-yl}-pyrazine

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Chemical Name:2-[2-(2-fluoro-phenyl)-pyridin-4-yl]-6-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-pyrazol-4-yl}-pyrazine
CAS No.:1354759-09-3
Molecular Formula:C₂₅H₂₄FN₅O₂
Molecular Weight:445.496
Hs Code.:

Synonyms:2-[2-(2-fluoro-phenyl)-pyridin-4-yl]-6-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-pyrazol-4-yl}-pyrazine

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Chemical Property of 2-[2-(2-fluoro-phenyl)-pyridin-4-yl]-6-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-pyrazol-4-yl}-pyrazine

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Technology Process of 2-[2-(2-fluoro-phenyl)-pyridin-4-yl]-6-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-pyrazol-4-yl}-pyrazine

There total 2 articles about 2-[2-(2-fluoro-phenyl)-pyridin-4-yl]-6-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-pyrazol-4-yl}-pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 956907-34-9
1-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1354759-08-2
2-chloro-6-[2-(2-fluoro-phenyl)-pyridin-4-yl]-pyrazine

: 1354759-09-3
2-[2-(2-fluoro-phenyl)-pyridin-4-yl]-6-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-pyrazol-4-yl}-pyrazine

Guidance literature:: With potassium phosphate tribasic trihydrate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; at 80 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1354759-05-9
2-(2-fluoro-phenyl)-pyridine-4-boronic acid

: 1354759-09-3
2-[2-(2-fluoro-phenyl)-pyridin-4-yl]-6-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-pyrazol-4-yl}-pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 7 h / 80 °C / Inert atmosphere

2: potassium phosphate tribasic trihydrate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 1 h / 80 °C / Inert atmosphere

With potassium phosphate tribasic trihydrate; sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;