Technology Process of N-(2-(4-aminophenyl)ethyl)-5-chloro-3-ethyl-1H-indole-2-carboxamide
There total 3 articles about N-(2-(4-aminophenyl)ethyl)-5-chloro-3-ethyl-1H-indole-2-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tin(II) chloride dihdyrate;
In
ethyl acetate;
at 60 ℃;
DOI:10.1021/jm201485c
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: aluminum (III) chloride / 1,2-dichloro-ethane / Reflux
2.1: triethylsilane; trifluoroacetic acid / 20 °C
3.1: sodium hydroxide / ethanol / 60 °C
3.2: pH 2
4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C
5.1: tin(II) chloride dihdyrate / ethyl acetate / 60 °C
With
triethylsilane; aluminum (III) chloride; tin(II) chloride dihdyrate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; sodium hydroxide;
In
ethanol; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
1.1: Friedel Crafts acylation;
DOI:10.1021/jm201485c
- Guidance literature:
-
Multi-step reaction with 2 steps
1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C
2: tin(II) chloride dihdyrate / ethyl acetate / 60 °C
With
tin(II) chloride dihdyrate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine;
In
ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm201485c
