Chemical Property of Nalmefene hydrochloride
Chemical Property:
- Vapor Pressure:3.88E-11mmHg at 25°C
- Melting Point:105-110oC
- Boiling Point:507.9 °C at 760 mmHg
- PKA:7.63(at 25℃)
- Flash Point:261 °C
- PSA：52.93000
- LogP:3.25240
- Storage Temp.:Desiccate at RT
- Solubility.:Soluble in Water (up to 25 mg/ml).
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:2
- Exact Mass:375.1601214
- Heavy Atom Count:26
- Complexity:618
- Purity/Quality:
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Nalmefenehydrochloride ≥99%(HPLC) *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:C=C1CCC2(C3CC4=C5C2(C1OC5=C(C=C4)O)CCN3CC6CC6)O.Cl
- Isomeric SMILES:C=C1CC[C@]2([C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3CC6CC6)O.Cl
- Recent ClinicalTrials:Clinical Outcomes From Nalmefene
- Recent NIPH Clinical Trials:None
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Description
Nalmefene hydrochloride has been introduced in the U.S.A. for opioid reversal
following surgery, and in the reversal of opioid overdoses and epidurally administered
narcotics. Nalmefene is an opioid antagonist that inhibits respiratory, analgesic and
subjective effects of opioids. It has a higher potency, a longer duration of action, and
superior bioavailability than the structurally related naltrexone. Nalmefene has a wide
spectrum of biological activity and is in clinical trials for the treatment of interstitial
cystitis, recalcitrant pruritus of cholestasis, stroke, rheumatoid arthritis, shock, CNS
trauma, and alcoholism. Studies indicate that nalmefene does not induce morphine-like
effects and has no apparent abuse potential.
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Uses
Nalmefene Hydrochloride is a structural analog of Naltrexone (N285780) with opiate antagonist activity used in pharmaceutical treatment of alcoholism. Other pharmacological applications of Nalmefene hydrochloride aim to reduce food cravings, drug abuse and pulmonary disease in affected individuals. Used as an opioid-induced tranquilizer on large animals in the veterinary industry. Narcotic antagonist
