Nalmefene hydrochloride

Base Information

• Chemical Name: Nalmefene hydrochloride
• CAS No.: 58895-64-0
• Molecular Formula: C₂₁H₂₅NO₃*ClH
• Molecular Weight: 375.895
• European Community (EC) Number: 641-080-2
• UNII: K7K69QC05X
• DSSTox Substance ID: DTXSID70891705
• Wikidata: Q27282058
• NCI Thesaurus Code: C47631
• RXCUI: 236069
• ChEMBL ID: CHEMBL1201152
• Mol file: 58895-64-0.mol

Synonyms:6-desoxy-6-methylenenaltrexone;nalmefene;nalmefene hydrochloride;opvee;Revex;Selincro

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Chemical Property of Nalmefene hydrochloride

Chemical Property:

• Vapor Pressure: 3.88E-11mmHg at 25°C
• Melting Point: 105-110oC
• Boiling Point: 507.9 °C at 760 mmHg
• PKA: 7.63(at 25℃)
• Flash Point: 261 °C
• PSA: 52.93000
• LogP: 3.25240
• Storage Temp.: Desiccate at RT
• Solubility.: Soluble in Water (up to 25 mg/ml).
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 375.1601214
• Heavy Atom Count: 26
• Complexity: 618

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C=C1CCC2(C3CC4=C5C2(C1OC5=C(C=C4)O)CCN3CC6CC6)O.Cl
• Isomeric SMILES: C=C1CC[C@]2([C@H]3CC4=C5[C@]2([C@H]1OC5=C(C=C4)O)CCN3CC6CC6)O.Cl
• Recent ClinicalTrials: Clinical Outcomes From Nalmefene
• Recent NIPH Clinical Trials: None
• Description: Nalmefene hydrochloride has been introduced in the U.S.A. for opioid reversal following surgery, and in the reversal of opioid overdoses and epidurally administered narcotics. Nalmefene is an opioid antagonist that inhibits respiratory, analgesic and subjective effects of opioids. It has a higher potency, a longer duration of action, and superior bioavailability than the structurally related naltrexone. Nalmefene has a wide spectrum of biological activity and is in clinical trials for the treatment of interstitial cystitis, recalcitrant pruritus of cholestasis, stroke, rheumatoid arthritis, shock, CNS trauma, and alcoholism. Studies indicate that nalmefene does not induce morphine-like effects and has no apparent abuse potential.
• Uses: Nalmefene Hydrochloride is a structural analog of Naltrexone (N285780) with opiate antagonist activity used in pharmaceutical treatment of alcoholism. Other pharmacological applications of this compound aim to reduce food cravings, drug abuse and pulmonary disease in affected individuals. Used as an opioid-induced tranquilizer on large animals in the veterinary industry. Narcotic antagonist