5-(2-amino-4-trifluoromethyl-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid amide

Base Information

• Chemical Name: 5-(2-amino-4-trifluoromethyl-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid amide
• CAS No.: 304874-19-9
• Molecular Formula: C₁₀H₉F₃N₆O
• Molecular Weight: 286.216

Synonyms:5-(2-amino-4-trifluoromethyl-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid amide

Chemical Property of 5-(2-amino-4-trifluoromethyl-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid amide

Chemical Property:

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Technology Process of 5-(2-amino-4-trifluoromethyl-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid amide

There total 3 articles about 5-(2-amino-4-trifluoromethyl-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-(2-nitro-4-trifluoromethyl-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid amide → 5-(2-amino-4-trifluoromethyl-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid amide (304874-19-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; under 760 Torr;

DOI:10.1016/S0223-5234(00)00180-X

Reference yield:

1-azido-2-nitro-4-(trifluoromethyl)benzene (51093-74-4) → 5-(2-amino-4-trifluoromethyl-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid amide (304874-19-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaOEt / ethanol

1.2: ethanol / -10 - 20 °C

2.1: aq. NaOH / Heating

3.1: 96 percent / H₂ / 10 percent Pd/C / methanol / 20 °C / 760 Torr

With sodium hydroxide; hydrogen; sodium ethanolate; palladium on activated charcoal; In methanol; ethanol; 1.1: Addition / 1.2: Cycloaddition / 2.1: Dimroth rearrangement / 3.1: Catalytic hydrogenation;

DOI:10.1016/S0223-5234(00)00180-X

Reference yield:

5-amino-1-(2-nitro-4-trifluoromethyl-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid amide → 5-(2-amino-4-trifluoromethyl-phenylamino)-1H-[1,2,3]triazole-4-carboxylic acid amide (304874-19-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / Heating

2: 96 percent / H₂ / 10 percent Pd/C / methanol / 20 °C / 760 Torr

With sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol; 1: Dimroth rearrangement / 2: Catalytic hydrogenation;

DOI:10.1016/S0223-5234(00)00180-X

upstream raw materials:

1-azido-2-nitro-4-(trifluoromethyl)benzene

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