6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

Base Information

Chemical Name:6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
CAS No.:1206800-21-6
Molecular Formula:C₁₈H₁₅BrFN₃O₄
Molecular Weight:436.237
Hs Code.:

Synonyms:6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

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Chemical Property of 6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

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Technology Process of 6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

There total 1 articles about 6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 1206800-19-2
6-bromo-5-(2-fluoro-4-nitrophenoxy)-1H-indazole

: 1206800-21-6
6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

Guidance literature:: 3,4-dihydro-2H-pyran; 6-bromo-5-(2-fluoro-4-nitrophenoxy)-1H-indazole; With methanesulfonic acid; In tetrahydrofuran; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield: 56.5%

: 110-91-8,99108-56-2
morpholine

: 1206800-21-6
6-bromo-5-(2-fluoro-4-nitrophenoxy)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

: 1206800-45-4
4-(5-(2-Fluoro-4-nitrophenoxy)-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-6-yl)morpholine

Guidance literature:: With potassium hydroxide; di-tert-butyl (2'-methyl-[1,1'-biphenyl]-2-yl)phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In water; tert-butyl alcohol; at 70 ℃; for 2h; Inert atmosphere;