N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-[methyl(phenylmethyl)amino]butanamide

Base Information

• Chemical Name: N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-[methyl(phenylmethyl)amino]butanamide
• CAS No.: 1621318-05-5
• Molecular Formula: C₃₅H₄₀N₆O₄S
• Molecular Weight: 640.806
• Mol file: 1621318-05-5.mol

Synonyms:N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-[methyl(phenylmethyl)amino]butanamide

Chemical Property of N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-[methyl(phenylmethyl)amino]butanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-[methyl(phenylmethyl)amino]butanamide

There total 7 articles about N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-[methyl(phenylmethyl)amino]butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

8-amino-3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl][1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (1621317-76-7) + 4-[methyl(phenylmethyl)amino]butanoic acid hydrochloride → N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-[methyl(phenylmethyl)amino]butanamide (1621318-05-5)

Guidance literature:

4-[methyl(phenylmethyl)amino]butanoic acid hydrochloride; With sodium carbonate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; for 1h; Reflux;

8-amino-3-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl][1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione; In tetrahydrofuran; for 28h; Reflux;

DOI:10.1016/j.ejmech.2014.06.057

Reference yield:

C12H8ClN3O4S (1621317-72-3) → N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-[methyl(phenylmethyl)amino]butanamide (1621318-05-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 0.5 h / 160 °C

2.1: hydrazine hydrate / N,N-dimethyl-formamide / 24 h / 20 °C

3.1: 1,1'-carbonyldiimidazole; sodium carbonate / tetrahydrofuran / 1 h / Reflux

3.2: 28 h / Reflux

With sodium carbonate; hydrazine hydrate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2014.06.057

Reference yield:

ethyl (3-amino-5-nitrobenzothiophen)-2-carboxylate (27697-60-5) → N-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxo-1,2,3,4-tetrahydro[1]benzothieno[3,2-d]pyrimidin-8-yl]-4-[methyl(phenylmethyl)amino]butanamide (1621318-05-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: toluene / 26 h / 20 °C / Reflux

2.1: 0.67 h / 50 °C

3.1: thionyl chloride / toluene / 22 h / 20 °C / Reflux

4.1: 0.5 h / 160 °C

5.1: hydrazine hydrate / N,N-dimethyl-formamide / 24 h / 20 °C

6.1: 1,1'-carbonyldiimidazole; sodium carbonate / tetrahydrofuran / 1 h / Reflux

6.2: 28 h / Reflux

With thionyl chloride; sodium carbonate; hydrazine hydrate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.ejmech.2014.06.057

upstream raw materials:

C₁₂H₈ClN₃O₄S

ethyl (3-amino-5-nitrobenzothiophen)-2-carboxylate

ethyl 3-[(ethoxycarbonyl)amino]-5-nitro-1-benzothiophene-2-carboxylate

3-(2-hydroxyethyl)-8-nitro[1]benzothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione