1-{6-[4-(1,1-dimethylpropyl)cyclohexyloxy]quinazolin-2-ylmethyl}pyrrolidine-3-carboxylic acid

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Chemical Name:1-{6-[4-(1,1-dimethylpropyl)cyclohexyloxy]quinazolin-2-ylmethyl}pyrrolidine-3-carboxylic acid
CAS No.:1266119-56-5
Molecular Formula:C₂₅H₃₅N₃O₃
Molecular Weight:425.571
Hs Code.:

Synonyms:1-{6-[4-(1,1-dimethylpropyl)cyclohexyloxy]quinazolin-2-ylmethyl}pyrrolidine-3-carboxylic acid

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Chemical Property of 1-{6-[4-(1,1-dimethylpropyl)cyclohexyloxy]quinazolin-2-ylmethyl}pyrrolidine-3-carboxylic acid

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Technology Process of 1-{6-[4-(1,1-dimethylpropyl)cyclohexyloxy]quinazolin-2-ylmethyl}pyrrolidine-3-carboxylic acid

There total 7 articles about 1-{6-[4-(1,1-dimethylpropyl)cyclohexyloxy]quinazolin-2-ylmethyl}pyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1266119-51-0
(R)-1-{6-[4-(1,1-dimethylpropyl)cyclohexyloxy]quinazolin-2-ylmethyl}-pyrrolidine-3-carboxylic acid methyl ester

: 1266119-56-5
1-{6-[4-(1,1-dimethylpropyl)cyclohexyloxy]quinazolin-2-ylmethyl}pyrrolidine-3-carboxylic acid

Guidance literature:: (R)-1-{6-[4-(1,1-dimethylpropyl)cyclohexyloxy]quinazolin-2-ylmethyl}-pyrrolidine-3-carboxylic acid methyl ester; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 23 ℃; for 0.166667h;

With hydrogenchloride; In water;

Reference yield:

: 20357-24-8
5-methoxy-2-nitro-benzaldehyde

: 1266119-56-5
1-{6-[4-(1,1-dimethylpropyl)cyclohexyloxy]quinazolin-2-ylmethyl}pyrrolidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen; sodium acetate; platinum(IV) oxide / ethyl acetate / 3 h / 2689.24 Torr / Inert atmosphere

1.2: 2 h / -20 °C

2.1: ammonia / ethanol / 2 h / -78 - 135 °C / High pressure

3.1: selenium(IV) oxide / 1,4-dioxane / 12 h / 90 °C

4.1: methanol / 0.5 h / 23 °C

4.2: 24 h / -30 - 23 °C

5.1: boron tribromide / dichloromethane / 3 h / -78 - 50 °C

5.2: 15 h / -78 - 23 °C

5.3: pH 7.5 - 9

6.1: triphenylphosphine / toluene; tetrahydrofuran / 12 h / 23 °C

7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.17 h / 23 °C

With platinum(IV) oxide; selenium(IV) oxide; ammonia; water; hydrogen; sodium acetate; boron tribromide; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; ethyl acetate; toluene;

Reference yield:

: 1266119-38-3
6-methoxy-2-methylquinazoline

: 1266119-56-5
1-{6-[4-(1,1-dimethylpropyl)cyclohexyloxy]quinazolin-2-ylmethyl}pyrrolidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: selenium(IV) oxide / 1,4-dioxane / 12 h / 90 °C

2.1: methanol / 0.5 h / 23 °C

2.2: 24 h / -30 - 23 °C

3.1: boron tribromide / dichloromethane / 3 h / -78 - 50 °C

3.2: 15 h / -78 - 23 °C

3.3: pH 7.5 - 9

4.1: triphenylphosphine / toluene; tetrahydrofuran / 12 h / 23 °C

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.17 h / 23 °C

With selenium(IV) oxide; water; boron tribromide; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;