(S)-2-((R,E)-5-azido-1-(benzyloxy)pent-3-en-2-yl)-1,4-dioxaspiro[4.5]decane

Base Information

Chemical Name:(S)-2-((R,E)-5-azido-1-(benzyloxy)pent-3-en-2-yl)-1,4-dioxaspiro[4.5]decane
CAS No.:1403589-80-9
Molecular Formula:C₂₀H₂₇N₃O₃
Molecular Weight:357.453
Hs Code.:

Synonyms:(S)-2-((R,E)-5-azido-1-(benzyloxy)pent-3-en-2-yl)-1,4-dioxaspiro[4.5]decane

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Chemical Property of (S)-2-((R,E)-5-azido-1-(benzyloxy)pent-3-en-2-yl)-1,4-dioxaspiro[4.5]decane

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Technology Process of (S)-2-((R,E)-5-azido-1-(benzyloxy)pent-3-en-2-yl)-1,4-dioxaspiro[4.5]decane

There total 5 articles about (S)-2-((R,E)-5-azido-1-(benzyloxy)pent-3-en-2-yl)-1,4-dioxaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₃₀O₆S

: 1403589-80-9
(S)-2-((R,E)-5-azido-1-(benzyloxy)pent-3-en-2-yl)-1,4-dioxaspiro[4.5]decane

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 100 ℃; for 4h;
DOI:10.1016/j.tetasy.2012.08.012

Reference yield:

: 1339946-62-1
(R)-2-((S)-1,4-dioxaspiro[4.5]decan-2-yl)-pent-4-en-1-ol

: 1403589-80-9
(S)-2-((R,E)-5-azido-1-(benzyloxy)pent-3-en-2-yl)-1,4-dioxaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.42 h / 0 °C / Inert atmosphere

1.2: 7 h / 0 - 20 °C / Inert atmosphere

2.1: palladium diacetate; p-benzoquinone / dimethyl sulfoxide / 48 h / 40 °C / Molecular sieve

3.1: sodium hydroxide / water; methanol / 0.5 h / 20 °C

4.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 4 h / 100 °C

With sodium azide; palladium diacetate; sodium hydride; triethylamine; p-benzoquinone; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tetasy.2012.08.012

Reference yield:

: 1403589-79-6
(R,E)-5-(benzyloxy)-4-((S)-1,4-dioxaspiro[4.5]decan-2-yl)pent-2-en-1-ol

: 1403589-80-9
(S)-2-((R,E)-5-azido-1-(benzyloxy)pent-3-en-2-yl)-1,4-dioxaspiro[4.5]decane

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

2: sodium azide / N,N-dimethyl-formamide / 4 h / 100 °C

With sodium azide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2012.08.012