benzyl 4-[(diethoxyphosphoryl)-difluoromethyl]-phenylacetate

Base Information

• Chemical Name: benzyl 4-[(diethoxyphosphoryl)-difluoromethyl]-phenylacetate
• CAS No.: 400796-66-9
• Molecular Formula: C₂₀H₂₃F₂O₅P
• Molecular Weight: 412.37
• Mol file: 400796-66-9.mol

Synonyms:benzyl 4-[(diethoxyphosphoryl)-difluoromethyl]-phenylacetate

Chemical Property of benzyl 4-[(diethoxyphosphoryl)-difluoromethyl]-phenylacetate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of benzyl 4-[(diethoxyphosphoryl)-difluoromethyl]-phenylacetate

There total 1 articles about benzyl 4-[(diethoxyphosphoryl)-difluoromethyl]-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

(4-iodophenyl)-acetic acid benzyl ester + diethyl (bromodifluoromethyl)phosphonate (65094-22-6) → benzyl 4-[(diethoxyphosphoryl)-difluoromethyl]-phenylacetate (400796-66-9)

Guidance literature:

diethyl (bromodifluoromethyl)phosphonate; With zinc; In N,N-dimethyl acetamide; for 1h;

With copper(I) bromide; In N,N-dimethyl acetamide; for 1h;

(4-iodophenyl)-acetic acid benzyl ester; In N,N-dimethyl acetamide; at 20 ℃; for 24h; sonification;

DOI:10.1002/anie.200462004

Reference yield:

benzyl 4-[(diethoxyphosphoryl)-difluoromethyl]-phenylacetate (400796-66-9) → {4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-acetic acid (634912-72-4)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 0 ℃; for 3h;

DOI:10.1002/anie.200462004

Reference yield:

benzyl 4-[(diethoxyphosphoryl)-difluoromethyl]-phenylacetate (400796-66-9) → 4-(phosphonodifluoromethyl)phenylacetic acid

Guidance literature:

Multi-step reaction with 2 steps

1: aq. LiOH / tetrahydrofuran / 3 h / 0 °C

2: 99 percent / trimethylsilylbromide / CH₂Cl₂ / 20 h / 20 °C

With lithium hydroxide; trimethylsilyl bromide; In tetrahydrofuran; dichloromethane;

DOI:10.1002/anie.200462004

upstream raw materials:

diethyl (bromodifluoromethyl)phosphonate

Downstream raw materials:

{4-[(diethoxy-phosphoryl)-difluoro-methyl]-phenyl}-acetic acid