Acetic acid (1S,2R)-2-azido-1-((R)-2-bromo-1-hydroxy-ethyl)-3-(4-methoxy-phenyl)-propyl ester

Base Information

Chemical Name:Acetic acid (1S,2R)-2-azido-1-((R)-2-bromo-1-hydroxy-ethyl)-3-(4-methoxy-phenyl)-propyl ester
CAS No.:173266-54-1
Molecular Formula:C₁₄H₁₈BrN₃O₄
Molecular Weight:372.219
Hs Code.:

Synonyms:Acetic acid (1S,2R)-2-azido-1-((R)-2-bromo-1-hydroxy-ethyl)-3-(4-methoxy-phenyl)-propyl ester

Suppliers and Price of Acetic acid (1S,2R)-2-azido-1-((R)-2-bromo-1-hydroxy-ethyl)-3-(4-methoxy-phenyl)-propyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Acetic acid (1S,2R)-2-azido-1-((R)-2-bromo-1-hydroxy-ethyl)-3-(4-methoxy-phenyl)-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Acetic acid (1S,2R)-2-azido-1-((R)-2-bromo-1-hydroxy-ethyl)-3-(4-methoxy-phenyl)-propyl ester

There total 12 articles about Acetic acid (1S,2R)-2-azido-1-((R)-2-bromo-1-hydroxy-ethyl)-3-(4-methoxy-phenyl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 173266-52-9
Acetic acid (1S,2R)-2-azido-3-(4-methoxy-phenyl)-1-(S)-oxiranyl-propyl ester

: 173266-54-1
Acetic acid (1S,2R)-2-azido-1-((R)-2-bromo-1-hydroxy-ethyl)-3-(4-methoxy-phenyl)-propyl ester

Guidance literature:: With lithium bromide; In tetrahydrofuran; acetic acid; for 24h; Ambient temperature;
DOI:10.1016/0957-4166(95)00383-5

Reference yield:

: 922-65-6
divinylcarbinol

: 173266-54-1
Acetic acid (1S,2R)-2-azido-1-((R)-2-bromo-1-hydroxy-ethyl)-3-(4-methoxy-phenyl)-propyl ester

Guidance literature:: Multi-step reaction with 12 steps

1: D-(-)-DIPT, TBHP, Ti(O-i-Pr)4 / CH₂Cl₂ / -20 °C

2: Et₃N, DMAP / CH₂Cl₂

3: 85 percent / copper(I) iodide / tetrahydrofuran / -10 °C

4: 94 percent / pyridine / CH₂Cl₂ / Ambient temperature

5: NaN₃ / dimethylformamide / 7 h / 80 °C

6: 2N aq. HCl / 0.5 h

7: 95 percent / OsO₄, K₃Fe(CN)6, K₂CO₃, DHQ-CLB, water / 2-methyl-propan-2-ol

8: 89 percent / imidazole / dimethylformamide / 0 °C

9: pyridine / CH₂Cl₂ / 2 h / Ambient temperature

10: pyridine / 4 h / Ambient temperature

11: 91 percent / n-Bu₄NF / tetrahydrofuran / 1 h / 0 °C

12: 90 percent / lithium bromide / acetic acid; tetrahydrofuran / 24 h / Ambient temperature

With pyridine; 1H-imidazole; titanium(IV) isopropylate; hydrogenchloride; tert.-butylhydroperoxide; dmap; copper(l) iodide; osmium(VIII) oxide; sodium azide; tetrabutyl ammonium fluoride; water; potassium carbonate; (1R)-((1S,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl 4-chlorobenzoate; D-(-)-diisopropyl tartrate; triethylamine; lithium bromide; potassium hexacyanoferrate(III); In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/0957-4166(95)00383-5

Reference yield:

: 102490-00-6
(2S,3R)-1,2-epoxy-4-penten-3-ol

: 173266-54-1
Acetic acid (1S,2R)-2-azido-1-((R)-2-bromo-1-hydroxy-ethyl)-3-(4-methoxy-phenyl)-propyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: Et₃N, DMAP / CH₂Cl₂

2: 85 percent / copper(I) iodide / tetrahydrofuran / -10 °C

3: 94 percent / pyridine / CH₂Cl₂ / Ambient temperature

4: NaN₃ / dimethylformamide / 7 h / 80 °C

5: 2N aq. HCl / 0.5 h

6: 95 percent / OsO₄, K₃Fe(CN)6, K₂CO₃, DHQ-CLB, water / 2-methyl-propan-2-ol

7: 89 percent / imidazole / dimethylformamide / 0 °C

8: pyridine / CH₂Cl₂ / 2 h / Ambient temperature

9: pyridine / 4 h / Ambient temperature

10: 91 percent / n-Bu₄NF / tetrahydrofuran / 1 h / 0 °C

11: 90 percent / lithium bromide / acetic acid; tetrahydrofuran / 24 h / Ambient temperature

With pyridine; 1H-imidazole; hydrogenchloride; dmap; copper(l) iodide; osmium(VIII) oxide; sodium azide; tetrabutyl ammonium fluoride; water; potassium carbonate; (1R)-((1S,4S,5R)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methyl 4-chlorobenzoate; triethylamine; lithium bromide; potassium hexacyanoferrate(III); In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/0957-4166(95)00383-5