N-({4-[(2R,3R)-3-{[(2R/S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]thio}-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenoxy}acetyl)glycyl-N₆,N₆-L-lysine

Base Information

• Chemical Name: N-({4-[(2R,3R)-3-{[(2R/S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]thio}-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenoxy}acetyl)glycyl-N₆,N₆-L-lysine
• CAS No.: 917815-15-7
• Molecular Formula: C₄₃H₅₇FN₄O₈SSi
• Molecular Weight: 837.097

Synonyms:N-({4-[(2R,3R)-3-{[(2R/S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]thio}-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenoxy}acetyl)glycyl-N₆,N₆-L-lysine

Chemical Property of N-({4-[(2R,3R)-3-{[(2R/S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]thio}-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenoxy}acetyl)glycyl-N₆,N₆-L-lysine

Chemical Property:

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Safty Information:

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Technology Process of N-({4-[(2R,3R)-3-{[(2R/S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]thio}-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenoxy}acetyl)glycyl-N₆,N₆-L-lysine

There total 2 articles about N-({4-[(2R,3R)-3-{[(2R/S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]thio}-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenoxy}acetyl)glycyl-N₆,N₆-L-lysine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-({4-[(2R,3R)-3-{[(2R/S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]thio}-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenoxy}acetyl)glycine (917815-12-4) + Nε,Nε-dimethyl-L-lysine hydrochloride (79416-87-8) → N-({4-[(2R,3R)-3-{[(2R/S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]thio}-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenoxy}acetyl)glycyl-N6,N6-L-lysine (917815-15-7)

Guidance literature:

N-({4-[(2R,3R)-3-{[(2R/S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]thio}-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenoxy}acetyl)glycine; With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 30 ℃; for 0.75h;

N^ε,N^ε-dimethyl-L-lysine hydrochloride; In N,N-dimethyl-formamide; for 2h;

Reference yield:

N-({4-[(2R,3R)-3-{[(2R/S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]thio}-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenoxy}acetyl)glycine methyl ester (917815-14-6) → N-({4-[(2R,3R)-3-{[(2R/S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]thio}-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenoxy}acetyl)glycyl-N6,N6-L-lysine (917815-15-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: water; triethylamine; lithium chloride / acetonitrile

2.1: 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.75 h / 30 °C

2.2: 2 h

With 4-methyl-morpholine; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; lithium chloride; In N,N-dimethyl-formamide; acetonitrile;

Reference yield:

N-({4-[(2R,3R)-3-{[(2R/S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]thio}-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenoxy}acetyl)glycyl-N6,N6-L-lysine (917815-15-7) → N-({4-[(2R,3R)-3-{[2-(2,3-dihydro-1-benzofuran-5-yl)-2-hydroxyethyl]thio}-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenoxy}acetyl)glycyl-N6,N6-L-lysine

Guidance literature:

With water; scandium tris(trifluoromethanesulfonate); In acetonitrile; for 5h;

upstream raw materials:

N-({4-[(2R,3R)-3-{[(2R/S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]thio}-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenoxy}acetyl)glycine

N^ε,N^ε-dimethyl-L-lysine hydrochloride

N-({4-[(2R,3R)-3-{[(2R/S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(2,3-dihydro-1-benzofuran-5-yl)ethyl]thio}-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenoxy}acetyl)glycine methyl ester

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