1-hydroxy-3-(2-(4'-(2-hydroxyethylamino)biphenyl-4-yl)-1,6-naphthyridin-4-yl)urea

Base Information

Chemical Name:1-hydroxy-3-(2-(4'-(2-hydroxyethylamino)biphenyl-4-yl)-1,6-naphthyridin-4-yl)urea
CAS No.:1620951-82-7
Molecular Formula:C₂₃H₂₁N₅O₃
Molecular Weight:415.451
Hs Code.:

Synonyms:1-hydroxy-3-(2-(4'-(2-hydroxyethylamino)biphenyl-4-yl)-1,6-naphthyridin-4-yl)urea

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Chemical Property of 1-hydroxy-3-(2-(4'-(2-hydroxyethylamino)biphenyl-4-yl)-1,6-naphthyridin-4-yl)urea

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Technology Process of 1-hydroxy-3-(2-(4'-(2-hydroxyethylamino)biphenyl-4-yl)-1,6-naphthyridin-4-yl)urea

There total 7 articles about 1-hydroxy-3-(2-(4'-(2-hydroxyethylamino)biphenyl-4-yl)-1,6-naphthyridin-4-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1620955-21-6
C₃₄H₄₃N₅O₄Si

: 1620951-82-7
1-hydroxy-3-(2-(4'-(2-hydroxyethylamino)biphenyl-4-yl)-1,6-naphthyridin-4-yl)urea

Guidance literature:: With hydrogenchloride; In dichloromethane; at 0 - 20 ℃; for 4h;

Reference yield:

: 1054478-77-1
2-(4-bromophenyl)-1,6-naphthyridine-4-carboxylic acid

: 1620951-82-7
1-hydroxy-3-(2-(4'-(2-hydroxyethylamino)biphenyl-4-yl)-1,6-naphthyridin-4-yl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; diphenyl phosphoryl azide / 18 h / Reflux

2.1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

3.1: triethylamine / toluene / 4 h / 0 - 100 °C

3.2: 14 h / 0 - 20 °C

4.1: potassium carbonate / tetrahydrofuran; water / 1 h / 20 °C / Inert atmosphere

4.2: 2.25 h / 20 - 70 °C / Inert atmosphere

5.1: hydrogenchloride / dichloromethane / 4 h / 0 - 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; toluene;

Reference yield:

: 1054480-13-5
2-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)amino)ethanol

: 1620951-82-7
1-hydroxy-3-(2-(4'-(2-hydroxyethylamino)biphenyl-4-yl)-1,6-naphthyridin-4-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / dichloromethane / 2 h / 0 °C

2.1: potassium carbonate / tetrahydrofuran; water / 1 h / 20 °C / Inert atmosphere

2.2: 2.25 h / 20 - 70 °C / Inert atmosphere

3.1: hydrogenchloride / dichloromethane / 4 h / 0 - 20 °C

With 1H-imidazole; hydrogenchloride; potassium carbonate; In tetrahydrofuran; dichloromethane; water;