O-(2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl-4-fluorobenzylcarbamothioate

Base Information

Chemical Name:O-(2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl-4-fluorobenzylcarbamothioate
CAS No.:1384521-63-4
Molecular Formula:C₁₈H₁₆FN₃O₂S
Molecular Weight:357.408
Hs Code.:

Synonyms:O-(2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl-4-fluorobenzylcarbamothioate

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Chemical Property of O-(2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl-4-fluorobenzylcarbamothioate

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Technology Process of O-(2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl-4-fluorobenzylcarbamothioate

There total 2 articles about O-(2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl-4-fluorobenzylcarbamothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 2740-88-7
4-fluorobenzylisothiocyanate

: 1378372-01-0
6-(hydroxymethyl)-2-methyl-1,4-dihydroquinazolin-4-one

: 1384521-63-4
O-(2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl-4-fluorobenzylcarbamothioate

Guidance literature:: 6-(hydroxymethyl)-2-methyl-1,4-dihydroquinazolin-4-one; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

4-fluorobenzylisothiocyanate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.2174/157340612800493665

Reference yield:

: 140-75-0
para-fluorobenzylamine

: 1384521-63-4
O-(2-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)methyl-4-fluorobenzylcarbamothioate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diethyl ether / 0.25 h / Cooling with ice

1.2: 24 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 24 h / 20 °C

2.2: 48 h / 20 °C

With sodium hydride; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.2174/157340612800493665