Technology Process of (2S,5S,6R)-2-Benzyloxymethyl-6-(1-hydroxy-non-2-ynyl)-1-aza-spiro[4.5]decane-1-carboxylic acid tert-butyl ester
There total 11 articles about (2S,5S,6R)-2-Benzyloxymethyl-6-(1-hydroxy-non-2-ynyl)-1-aza-spiro[4.5]decane-1-carboxylic acid tert-butyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 90 percent / Na2CO3 / benzene / 20 °C
2.1: 96 percent / Bu4NF / tetrahydrofuran / 20 °C
3.1: 93 percent / pyridine / 20 °C
4.1: 85 percent / OsO4; NaIO4 / tetrahydrofuran; H2O / 20 °C
5.1: pyrrolidine / toluene / Heating
5.2: 60 percent / ag. AcOH / 20 °C
6.1: tetrahydrofuran / 0 °C
With
pyrrolidine; pyridine; sodium periodate; osmium(VIII) oxide; tetrabutyl ammonium fluoride; sodium carbonate;
In
tetrahydrofuran; water; toluene; benzene;
6.1: Grignard reaction;
DOI:10.1016/j.tetlet.2004.05.142
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 85 percent / tetrahydrofuran / 0 °C
2.1: TFA / CH2Cl2 / 0 - 20 °C
2.2: 87 percent / NaOH / 0 °C
3.1: 79 percent / DMAP; TEA / CH2Cl2
4.1: 74 percent / BF3Et20 / tetrahydrofuran / -78 °C
5.1: 90 percent / Na2CO3 / benzene / 20 °C
6.1: 96 percent / Bu4NF / tetrahydrofuran / 20 °C
7.1: 93 percent / pyridine / 20 °C
8.1: 85 percent / OsO4; NaIO4 / tetrahydrofuran; H2O / 20 °C
9.1: pyrrolidine / toluene / Heating
9.2: 60 percent / ag. AcOH / 20 °C
10.1: tetrahydrofuran / 0 °C
With
pyrrolidine; pyridine; dmap; sodium periodate; osmium(VIII) oxide; TEA; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; sodium carbonate; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; water; toluene; benzene;
1.1: Grignard reaction / 4.1: Grignard reaction / 10.1: Grignard reaction;
DOI:10.1016/j.tetlet.2004.05.142
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 79 percent / DMAP; TEA / CH2Cl2
2.1: 74 percent / BF3Et20 / tetrahydrofuran / -78 °C
3.1: 90 percent / Na2CO3 / benzene / 20 °C
4.1: 96 percent / Bu4NF / tetrahydrofuran / 20 °C
5.1: 93 percent / pyridine / 20 °C
6.1: 85 percent / OsO4; NaIO4 / tetrahydrofuran; H2O / 20 °C
7.1: pyrrolidine / toluene / Heating
7.2: 60 percent / ag. AcOH / 20 °C
8.1: tetrahydrofuran / 0 °C
With
pyrrolidine; pyridine; dmap; sodium periodate; osmium(VIII) oxide; TEA; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; sodium carbonate;
In
tetrahydrofuran; dichloromethane; water; toluene; benzene;
2.1: Grignard reaction / 8.1: Grignard reaction;
DOI:10.1016/j.tetlet.2004.05.142
