N-{4-[3-(tert-butyloxycarbonylamino)propanoylaminomethyl]benzoyl}methionine methyl ester

Base Information

Chemical Name:N-{4-[3-(tert-butyloxycarbonylamino)propanoylaminomethyl]benzoyl}methionine methyl ester
CAS No.:309957-40-2
Molecular Formula:C₂₂H₃₃N₃O₆S
Molecular Weight:467.587
Hs Code.:

Synonyms:N-{4-[3-(tert-butyloxycarbonylamino)propanoylaminomethyl]benzoyl}methionine methyl ester

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Chemical Property of N-{4-[3-(tert-butyloxycarbonylamino)propanoylaminomethyl]benzoyl}methionine methyl ester

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Technology Process of N-{4-[3-(tert-butyloxycarbonylamino)propanoylaminomethyl]benzoyl}methionine methyl ester

There total 4 articles about N-{4-[3-(tert-butyloxycarbonylamino)propanoylaminomethyl]benzoyl}methionine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 3303-84-2
3-(tert-butyloxycarbonylamino)propionic acid

: (S)-2-(4-Aminomethyl-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester; hydrochloride

: 309957-40-2
N-{4-[3-(tert-butyloxycarbonylamino)propanoylaminomethyl]benzoyl}methionine methyl ester

Guidance literature:: 3-(tert-butyloxycarbonylamino)propionic acid; With 4-methyl-morpholine; isobutyl chloroformate; In N,N-dimethyl-formamide; at -15 ℃; for 0.0833333h;

(S)-2-(4-Aminomethyl-benzoylamino)-4-methylsulfanyl-butyric acid methyl ester; hydrochloride; In N,N-dimethyl-formamide; at -15 - 20 ℃;
DOI:10.1016/S0968-0896(00)00173-5

Reference yield:

: 33233-67-9
4-(tert-Butoxycarbonylaminomethyl)benzoic acid

: 309957-40-2
N-{4-[3-(tert-butyloxycarbonylamino)propanoylaminomethyl]benzoyl}methionine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: isobutyl chloroformate; N-methylmorpholine / dimethylformamide / 0.08 h / -15 °C

1.2: 55 percent / dimethylformamide / -15 - 20 °C

2.1: aq. HCl / dioxane / 2 h / 20 °C

3.1: isobutyl chloroformate; N-methylmorpholine / dimethylformamide / 0.08 h / -15 °C

3.2: 75 percent / dimethylformamide / -15 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; isobutyl chloroformate; In 1,4-dioxane; N,N-dimethyl-formamide; 1.1: Acylation / 1.2: Acylation / 2.1: carbamate cleavage / 3.1: Acylation / 3.2: Acylation;
DOI:10.1016/S0968-0896(00)00173-5

Reference yield:

: 2491-18-1
(S)-methyl 2-amino-4-(methylthio)butanoate hydrochloride

: 309957-40-2
N-{4-[3-(tert-butyloxycarbonylamino)propanoylaminomethyl]benzoyl}methionine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: isobutyl chloroformate; N-methylmorpholine / dimethylformamide / 0.08 h / -15 °C

1.2: 55 percent / dimethylformamide / -15 - 20 °C

2.1: aq. HCl / dioxane / 2 h / 20 °C

3.1: isobutyl chloroformate; N-methylmorpholine / dimethylformamide / 0.08 h / -15 °C

3.2: 75 percent / dimethylformamide / -15 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; isobutyl chloroformate; In 1,4-dioxane; N,N-dimethyl-formamide; 1.1: Acylation / 1.2: Acylation / 2.1: carbamate cleavage / 3.1: Acylation / 3.2: Acylation;
DOI:10.1016/S0968-0896(00)00173-5