methyl (3R)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-(methoxymethoxy)butanoate

Base Information

Chemical Name:methyl (3R)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-(methoxymethoxy)butanoate
CAS No.:905291-67-0
Molecular Formula:C₂₂H₂₃NO₆
Molecular Weight:397.428
Hs Code.:

Synonyms:methyl (3R)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-(methoxymethoxy)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (3R)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-(methoxymethoxy)butanoate

Chemical Property:

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Technology Process of methyl (3R)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-(methoxymethoxy)butanoate

There total 11 articles about methyl (3R)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-(methoxymethoxy)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 905291-66-9
methyl (3R)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-hydroxybutanoate

: 107-30-2
chloromethyl methyl ether

: 905291-67-0
methyl (3R)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-(methoxymethoxy)butanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2006.03.032

Reference yield:

: 70681-41-3
(R)-dimethyl malate

: 905291-67-0
methyl (3R)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-(methoxymethoxy)butanoate

Guidance literature:: Multi-step reaction with 6 steps

1: borane dimethylsulfide complex; sodium borohydride / tetrahydrofuran / 0 - 20 °C

2: 50 percent / pyridine / 20 °C

3: 84 percent / sodium azide / dimethylformamide / 0.33 h / 80 °C

4: hydrogen; HCl / palladium on carbon / methanol / 2 h / 20 °C / atmospheric pressure

5: triethylamine / CH₂Cl₂ / 2 h / 20 °C

6: 75 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 20 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; sodium azide; dimethylsulfide borane complex; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.03.032

Reference yield:

: 98437-24-2
benzofuran-2-boronic acid

: 905291-67-0
methyl (3R)-4-{[4-(1-benzofuran-2-yl)benzoyl]amino}-3-(methoxymethoxy)butanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / triethylamine / dichlorobis(triphenylphosphine)palladium(II) / dimethylformamide / 6 h / 80 °C

2: 69 percent / sodium hydroxide / dioxane; H₂O / 9 h / 20 °C

3: 88 percent / SOCl₂ / 3 h / Heating

4: triethylamine / CH₂Cl₂ / 2 h / 20 °C

5: 75 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 20 °C

With sodium hydroxide; thionyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.03.032