N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-((2S)-pent-4-en-2-yloxy)pyrazine-2-carboxamide

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Chemical Name:N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-((2S)-pent-4-en-2-yloxy)pyrazine-2-carboxamide
CAS No.:1403480-60-3
Molecular Formula:C₃₃H₄₃FN₄O₇S
Molecular Weight:658.791
Hs Code.:

N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-((2S)-pent-4-en-2-yloxy)pyrazine-2-carboxamide

Synonyms:N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-((2S)-pent-4-en-2-yloxy)pyrazine-2-carboxamide

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Chemical Property of N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-((2S)-pent-4-en-2-yloxy)pyrazine-2-carboxamide

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Technology Process of N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-((2S)-pent-4-en-2-yloxy)pyrazine-2-carboxamide

There total 10 articles about N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-((2S)-pent-4-en-2-yloxy)pyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1403480-35-2
N-((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-((2S)-pent-4-en-2-yloxy)pyrazine-2-carboxamide

: 1403480-60-3
N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-((2S)-pent-4-en-2-yloxy)pyrazine-2-carboxamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1021/jm500994n

Reference yield:

: 1255212-77-1
tert-butyl ((2R,3S)-2-((tert-butyldimethylsilyl)oxy)-4-(((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)amino)-3-methyl-4-oxobutyl)(methyl)carbamate

: 1403480-60-3
N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-((2S)-pent-4-en-2-yloxy)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 2,6-dimethylpyridine / dichloromethane / 3.92 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate / tetrahydrofuran; methanol; water / 3 h / 20 °C

3: 2,6-dimethylpyridine / dichloromethane / 18 h / 20 °C

4: dimethylsulfide borane complex / tetrahydrofuran / 6.25 h / 0 - 65 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 1.5 h / 0 - 20 °C

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C

With 2,6-dimethylpyridine; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm500994n

Reference yield:

: C₃₀H₅₆N₂O₆Si₂

: 1403480-60-3
N-((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)-N-((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-3-((2S)-pent-4-en-2-yloxy)pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / tetrahydrofuran; methanol; water / 3 h / 20 °C

2: 2,6-dimethylpyridine / dichloromethane / 18 h / 20 °C

3: dimethylsulfide borane complex / tetrahydrofuran / 6.25 h / 0 - 65 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride / dichloromethane / 1.5 h / 0 - 20 °C

5: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C

With 2,6-dimethylpyridine; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm500994n