N-(4-chlorobenzyl)-N',N'-[3-(4⁽⁵⁾-1H-imidazolyl)pentamethylene]thiourea

Base Information

Chemical Name:N-(4-chlorobenzyl)-N',N'-[3-(4⁽⁵⁾-1H-imidazolyl)pentamethylene]thiourea
CAS No.:159147-62-3
Molecular Formula:C₁₆H₁₉ClN₄S
Molecular Weight:334.873
Hs Code.:

N-(4-chlorobenzyl)-N',N'-[3-(4<sup>(5)</sup>-1H-imidazolyl)pentamethylene]thiourea

Synonyms:N-(4-chlorobenzyl)-N',N'-[3-(4⁽⁵⁾-1H-imidazolyl)pentamethylene]thiourea

Suppliers and Price of N-(4-chlorobenzyl)-N',N'-[3-(4⁽⁵⁾-1H-imidazolyl)pentamethylene]thiourea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-chlorobenzyl)-N',N'-[3-(4⁽⁵⁾-1H-imidazolyl)pentamethylene]thiourea

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Technology Process of N-(4-chlorobenzyl)-N',N'-[3-(4⁽⁵⁾-1H-imidazolyl)pentamethylene]thiourea

There total 6 articles about N-(4-chlorobenzyl)-N',N'-[3-(4⁽⁵⁾-1H-imidazolyl)pentamethylene]thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 3694-45-9
4-chlorobenzylisothiocyanate

: 106243-23-6
4-(1H-imidazol-4-yl)-piperidine

: 159147-62-3
N-(4-chlorobenzyl)-N',N'-[3-(4⁽⁵⁾-1H-imidazolyl)pentamethylene]thiourea

Guidance literature:: In toluene; for 6h; Heating;
DOI:10.1248/cpb.45.305

Reference yield:

: 273218-93-2
4-[1-(N,N-dimethylsulfamoyl)imidazol-4-yl]-4-hydroxypiperidine

: 159147-62-3
N-(4-chlorobenzyl)-N',N'-[3-(4⁽⁵⁾-1H-imidazolyl)pentamethylene]thiourea

Guidance literature:: Multi-step reaction with 3 steps

1: 74 percent / 30percent aq. HBr / 3 h / Heating

2: 100 percent / H₂ / 10percent Pd/C / methanol; H₂O / 4 h / 20 °C / 37503.8 Torr

3: diisopropylethylamine / ethanol / 18 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; 10percent Pd/C; In methanol; ethanol; water; 1: Hydrolysis / 2: Catalytic hydrogenation / 3: Addition;
DOI:10.1021/jm981106w

Reference yield:

: 273218-92-1
1-benzyl-4-[1-(N,N-dimethylsulfamoyl)imidazol-4-yl]-4-hydroxypiperidine

: 159147-62-3
N-(4-chlorobenzyl)-N',N'-[3-(4⁽⁵⁾-1H-imidazolyl)pentamethylene]thiourea

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / ammonium formate / 10percent Pd/C / methanol / 6 h / Heating

2: 74 percent / 30percent aq. HBr / 3 h / Heating

3: 100 percent / H₂ / 10percent Pd/C / methanol; H₂O / 4 h / 20 °C / 37503.8 Torr

4: diisopropylethylamine / ethanol / 18 h / 20 °C

With hydrogen; ammonium formate; N-ethyl-N,N-diisopropylamine; 10percent Pd/C; In methanol; ethanol; water; 1: Hydrogenolysis / 2: Hydrolysis / 3: Catalytic hydrogenation / 4: Addition;
DOI:10.1021/jm981106w