2-((3-methoxy-4-(3-(trifluoromethyl)phenoxy)benzyl)thio)-5-((1-methyl-1H-pyrazol-4-yl)methyl)pyrimidin-4(1H)-one

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Chemical Name:2-((3-methoxy-4-(3-(trifluoromethyl)phenoxy)benzyl)thio)-5-((1-methyl-1H-pyrazol-4-yl)methyl)pyrimidin-4(1H)-one
CAS No.:1380427-95-1
Molecular Formula:C₂₄H₂₁F₃N₄O₃S
Molecular Weight:502.517
Hs Code.:

Synonyms:2-((3-methoxy-4-(3-(trifluoromethyl)phenoxy)benzyl)thio)-5-((1-methyl-1H-pyrazol-4-yl)methyl)pyrimidin-4(1H)-one

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Chemical Property of 2-((3-methoxy-4-(3-(trifluoromethyl)phenoxy)benzyl)thio)-5-((1-methyl-1H-pyrazol-4-yl)methyl)pyrimidin-4(1H)-one

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Technology Process of 2-((3-methoxy-4-(3-(trifluoromethyl)phenoxy)benzyl)thio)-5-((1-methyl-1H-pyrazol-4-yl)methyl)pyrimidin-4(1H)-one

There total 5 articles about 2-((3-methoxy-4-(3-(trifluoromethyl)phenoxy)benzyl)thio)-5-((1-methyl-1H-pyrazol-4-yl)methyl)pyrimidin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.6%

: 224776-34-5
5-[(1-methyl-1H-pyrazol-4-yl)methyl]-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone

: 1369254-79-4
(3-(methyloxy)-4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)methanol

: 1380427-95-1
2-((3-methoxy-4-(3-(trifluoromethyl)phenoxy)benzyl)thio)-5-((1-methyl-1H-pyrazol-4-yl)methyl)pyrimidin-4(1H)-one

Guidance literature:: (3-(methyloxy)-4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)methanol; With thionyl chloride; In chloroform; at 20 ℃; for 2h;

5-[(1-methyl-1H-pyrazol-4-yl)methyl]-2-thioxo-2,3-dihydro-4(1H)-pyrimidinone; With N-ethyl-N,N-diisopropylamine; In chloroform; at 60 ℃; for 1h;

Reference yield:

: 25016-11-9
1-methylpyrazole-4-carbaldehyde

: 1380427-95-1
2-((3-methoxy-4-(3-(trifluoromethyl)phenoxy)benzyl)thio)-5-((1-methyl-1H-pyrazol-4-yl)methyl)pyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: piperidine; pyridine / 4 h / 110 °C / Inert atmosphere

1.2: pH 1

2.1: methanol; sulfuric acid / 4 h / Reflux

3.1: hydrogen / palladium on activated charcoal / ethanol / 12 h / 20 - 40 °C

4.1: potassium tert-butylate / tetrahydrofuran / 20 °C / Cooling with ice; Inert atmosphere

4.2: 50 °C

4.3: 1 h / pH 3 / Cooling with ice

5.1: thionyl chloride / chloroform / 2 h / 20 °C

5.2: 1 h / 60 °C

With piperidine; pyridine; methanol; thionyl chloride; sulfuric acid; potassium tert-butylate; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform;

Reference yield:

: 689251-97-6
(E)-3-(1-methyl-1H-pyrazol-4-yl)acrylic acid

: 1380427-95-1
2-((3-methoxy-4-(3-(trifluoromethyl)phenoxy)benzyl)thio)-5-((1-methyl-1H-pyrazol-4-yl)methyl)pyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; sulfuric acid / 4 h / Reflux

2.1: hydrogen / palladium on activated charcoal / ethanol / 12 h / 20 - 40 °C

3.1: potassium tert-butylate / tetrahydrofuran / 20 °C / Cooling with ice; Inert atmosphere

3.2: 50 °C

3.3: 1 h / pH 3 / Cooling with ice

4.1: thionyl chloride / chloroform / 2 h / 20 °C

4.2: 1 h / 60 °C

With methanol; thionyl chloride; sulfuric acid; potassium tert-butylate; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform;