α-D-5'-O-(tert-butyldiphenylsilyl)-2',3'-dideoxy-5-fluoro-2'-(phenylselenenyl)cytidine

Base Information

Chemical Name:α-D-5'-O-(tert-butyldiphenylsilyl)-2',3'-dideoxy-5-fluoro-2'-(phenylselenenyl)cytidine
CAS No.:221156-14-5
Molecular Formula:C₃₁H₃₄FN₃O₃SeSi
Molecular Weight:622.673
Hs Code.:

Synonyms:α-D-5'-O-(tert-butyldiphenylsilyl)-2',3'-dideoxy-5-fluoro-2'-(phenylselenenyl)cytidine

Suppliers and Price of α-D-5'-O-(tert-butyldiphenylsilyl)-2',3'-dideoxy-5-fluoro-2'-(phenylselenenyl)cytidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of α-D-5'-O-(tert-butyldiphenylsilyl)-2',3'-dideoxy-5-fluoro-2'-(phenylselenenyl)cytidine

Chemical Property:

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Technology Process of α-D-5'-O-(tert-butyldiphenylsilyl)-2',3'-dideoxy-5-fluoro-2'-(phenylselenenyl)cytidine

There total 1 articles about α-D-5'-O-(tert-butyldiphenylsilyl)-2',3'-dideoxy-5-fluoro-2'-(phenylselenenyl)cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 149656-26-8
1-O-acetyl-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-2-(phenylselenenyl)-D-erythro-pentafuranose

: 168332-11-4
5-Fluoro-1-trimethylsilanyl-4-(trimethylsilanyl-amino)-1H-pyrimidin-2-one

: 221156-14-5
α-D-5'-O-(tert-butyldiphenylsilyl)-2',3'-dideoxy-5-fluoro-2'-(phenylselenenyl)cytidine

: 221156-13-4
β-D-5'-O-(tert-butyldiphenylsilyl)-2',3'-dideoxy-5-fluoro-2'-(phenylselenenyl)cytidine

Guidance literature:: With tin(IV) chloride; Yield given; Multistep reaction. Yields of byproduct given; 1.) CH₂Cl₂, RT, 15 min, 2.) CH₂Cl₂, 0 deg C, 2 h;
DOI:10.1021/jm980510s

Reference yield: 95.0%

: 221156-14-5
α-D-5'-O-(tert-butyldiphenylsilyl)-2',3'-dideoxy-5-fluoro-2'-(phenylselenenyl)cytidine

: α-D-5'-O-(tert-butyldiphenylsilyl)-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine

Guidance literature:: With pyridine; dihydrogen peroxide; In dichloromethane; at 0 - 20 ℃; for 0.833333h;
DOI:10.1021/jm980510s

Reference yield:

: 221156-14-5
α-D-5'-O-(tert-butyldiphenylsilyl)-2',3'-dideoxy-5-fluoro-2'-(phenylselenenyl)cytidine

: 4-Amino-5-fluoro-1-((2S,5S)-5-hydroxymethyl-2,5-dihydro-furan-2-yl)-1H-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / 30 percent H₂O₂, pyridine / CH₂Cl₂ / 0.83 h / 0 - 20 °C

2: 91 percent / TBAF / tetrahydrofuran / 1.5 h / Ambient temperature

With pyridine; tetrabutyl ammonium fluoride; dihydrogen peroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm980510s