(1H-indol-3-ylcarbonyl)-Asp-Phe-NMeBzl

Base Information

• Chemical Name: (1H-indol-3-ylcarbonyl)-Asp-Phe-NMeBzl
• CAS No.: 131949-12-7
• Molecular Formula: C₃₀H₃₀N₄O₅
• Molecular Weight: 526.592
• Mol file: 131949-12-7.mol

Synonyms:(1H-indol-3-ylcarbonyl)-Asp-Phe-NMeBzl

Chemical Property of (1H-indol-3-ylcarbonyl)-Asp-Phe-NMeBzl

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1H-indol-3-ylcarbonyl)-Asp-Phe-NMeBzl

There total 6 articles about (1H-indol-3-ylcarbonyl)-Asp-Phe-NMeBzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.3%

(1H-indol-3-ylcarbonyl)-Asp(OBzl)-Phe-NMeBzl (131948-62-4) → (1H-indol-3-ylcarbonyl)-Asp-Phe-NMeBzl (131949-12-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; for 4h; under 760 Torr;

DOI:10.1021/jm00068a003

Reference yield:

1H-indole-3-carboxylic acid (771-50-6) → (1H-indol-3-ylcarbonyl)-Asp-Phe-NMeBzl (131949-12-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / oxalyl chloride / CH₂Cl₂ / 3 h / Heating

2: 93.6 percent / bis(trimethylsilyl)acetamide / CH₂Cl₂ / 2 h / 0 °C

3: 87.3 percent / H₂ / 5percent Pd/C / ethanol; tetrahydrofuran / 4 h / 760 Torr

With oxalyl dichloride; hydrogen; bis-(trimethylsilyl)acetamide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm00068a003

Reference yield:

Indole-3-carbonyl chloride (59496-25-2) → (1H-indol-3-ylcarbonyl)-Asp-Phe-NMeBzl (131949-12-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 93.6 percent / bis(trimethylsilyl)acetamide / CH₂Cl₂ / 2 h / 0 °C

2: 87.3 percent / H₂ / 5percent Pd/C / ethanol; tetrahydrofuran / 4 h / 760 Torr

With hydrogen; bis-(trimethylsilyl)acetamide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm00068a003

upstream raw materials:

(1H-indol-3-ylcarbonyl)-Asp(OBzl)-Phe-NMeBzl

1H-indole-3-carboxylic acid

Indole-3-carbonyl chloride

N-methyl-N-(phenylmethyl)-L-phenylalaninamide hydrochloride

Refernces