N-(4-bromobenzyl-1-carbonyl)-glycyl-glycyl-glycyl-glycine methyl ester

Base Information

Chemical Name:N-(4-bromobenzyl-1-carbonyl)-glycyl-glycyl-glycyl-glycine methyl ester
CAS No.:356570-67-7
Molecular Formula:C₁₆H₁₉BrN₄O₆
Molecular Weight:443.254
Hs Code.:

Synonyms:N-(4-bromobenzyl-1-carbonyl)-glycyl-glycyl-glycyl-glycine methyl ester

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Chemical Property of N-(4-bromobenzyl-1-carbonyl)-glycyl-glycyl-glycyl-glycine methyl ester

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Technology Process of N-(4-bromobenzyl-1-carbonyl)-glycyl-glycyl-glycyl-glycine methyl ester

There total 8 articles about N-(4-bromobenzyl-1-carbonyl)-glycyl-glycyl-glycyl-glycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 313958-35-9
N-(4-bromobenzyl-1-carbonyl)-glycyl-glycine

: 13059-60-4
glycylglycine hydrochloride

: 356570-67-7
N-(4-bromobenzyl-1-carbonyl)-glycyl-glycyl-glycyl-glycine methyl ester

Guidance literature:: glycylglycine hydrochloride; With triethylamine; In N,N-dimethyl-formamide; for 0.166667h;

N-(4-bromobenzyl-1-carbonyl)-glycyl-glycine; In N,N-dimethyl-formamide; for 0.166667h;

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; water; N,N-dimethyl-formamide; at -10 - 20 ℃;
DOI:10.1016/j.molstruc.2011.03.058

Reference yield:

: 586-76-5
4-Bromobenzoic acid

: 356570-67-7
N-(4-bromobenzyl-1-carbonyl)-glycyl-glycyl-glycyl-glycine methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 93.4 percent / diisopropylethylamine / 4-dymethylaminopyridine / CH₂Cl₂

2: 85 percent / KOH / methanol; H₂O / 3 h

3: diisopropylethylamine / 4-dimethylaminopyridine / CH₂Cl₂

4: 90.7 percent / LiOH*H₂O / H₂O; methanol

5: 82.8 percent / diisopropylethylamine / 4-dimethylaminopyridine / CH₂Cl₂

6: LiOH*H₂O / H₂O; methanol

7: 61 percent / diisopropylethylamine; 1-hydroxybenzotriazole / 4-dimethylaminopyridine / CH₂Cl₂

With potassium hydroxide; lithium hydroxide; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dmap; In methanol; dichloromethane; water;
DOI:10.1021/ol0160452

Reference yield:

: 138119-50-3
N-(4-bromobenzyl-1-carbonyl)-glycine methyl ester

: 356570-67-7
N-(4-bromobenzyl-1-carbonyl)-glycyl-glycyl-glycyl-glycine methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 85 percent / KOH / methanol; H₂O / 3 h

2: diisopropylethylamine / 4-dimethylaminopyridine / CH₂Cl₂

3: 90.7 percent / LiOH*H₂O / H₂O; methanol

4: 82.8 percent / diisopropylethylamine / 4-dimethylaminopyridine / CH₂Cl₂

5: LiOH*H₂O / H₂O; methanol

6: 61 percent / diisopropylethylamine; 1-hydroxybenzotriazole / 4-dimethylaminopyridine / CH₂Cl₂

With potassium hydroxide; lithium hydroxide; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dmap; In methanol; dichloromethane; water;
DOI:10.1021/ol0160452