3-{(S)-2-[(S)-2-((S)-5-Guanidino-2-{(S)-3-(4-hydroxy-phenyl)-2-[(S)-2-(2-methanesulfonyl-ethoxycarbonylamino)-4-methyl-pentanoylamino]-propionylamino}-pentanoylamino)-propionylamino]-4-methyl-pentanoylsulfanyl}-propionic acid ethyl ester

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Chemical Name:3-{(S)-2-[(S)-2-((S)-5-Guanidino-2-{(S)-3-(4-hydroxy-phenyl)-2-[(S)-2-(2-methanesulfonyl-ethoxycarbonylamino)-4-methyl-pentanoylamino]-propionylamino}-pentanoylamino)-propionylamino]-4-methyl-pentanoylsulfanyl}-propionic acid ethyl ester
CAS No.:640266-23-5
Molecular Formula:C₃₉H₆₄N₈O₁₂S₂
Molecular Weight:901.116
Hs Code.:

3-{(S)-2-[(S)-2-((S)-5-Guanidino-2-{(S)-3-(4-hydroxy-phenyl)-2-[(S)-2-(2-methanesulfonyl-ethoxycarbonylamino)-4-methyl-pentanoylamino]-propionylamino}-pentanoylamino)-propionylamino]-4-methyl-pentanoylsulfanyl}-propionic acid ethyl ester

Synonyms:3-{(S)-2-[(S)-2-((S)-5-Guanidino-2-{(S)-3-(4-hydroxy-phenyl)-2-[(S)-2-(2-methanesulfonyl-ethoxycarbonylamino)-4-methyl-pentanoylamino]-propionylamino}-pentanoylamino)-propionylamino]-4-methyl-pentanoylsulfanyl}-propionic acid ethyl ester

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Chemical Property of 3-{(S)-2-[(S)-2-((S)-5-Guanidino-2-{(S)-3-(4-hydroxy-phenyl)-2-[(S)-2-(2-methanesulfonyl-ethoxycarbonylamino)-4-methyl-pentanoylamino]-propionylamino}-pentanoylamino)-propionylamino]-4-methyl-pentanoylsulfanyl}-propionic acid ethyl ester

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Technology Process of 3-{(S)-2-[(S)-2-((S)-5-Guanidino-2-{(S)-3-(4-hydroxy-phenyl)-2-[(S)-2-(2-methanesulfonyl-ethoxycarbonylamino)-4-methyl-pentanoylamino]-propionylamino}-pentanoylamino)-propionylamino]-4-methyl-pentanoylsulfanyl}-propionic acid ethyl ester

There total 1 articles about 3-{(S)-2-[(S)-2-((S)-5-Guanidino-2-{(S)-3-(4-hydroxy-phenyl)-2-[(S)-2-(2-methanesulfonyl-ethoxycarbonylamino)-4-methyl-pentanoylamino]-propionylamino}-pentanoylamino)-propionylamino]-4-methyl-pentanoylsulfanyl}-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5466-06-8
3-mercaptopropionic acid ethyl ester

: 35661-39-3,136132-75-7
N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

: 91000-69-0,130752-32-8
Fmoc-L-Arg-OH

: 57903-15-8
2-(methylsulfonyl)ethyl succinimidyl carbonate

: 640266-23-5
3-{(S)-2-[(S)-2-((S)-5-Guanidino-2-{(S)-3-(4-hydroxy-phenyl)-2-[(S)-2-(2-methanesulfonyl-ethoxycarbonylamino)-4-methyl-pentanoylamino]-propionylamino}-pentanoylamino)-propionylamino]-4-methyl-pentanoylsulfanyl}-propionic acid ethyl ester

Guidance literature:: Multistep reaction;
DOI:10.1021/ol035742m

Reference yield: 80.0%

: 640266-23-5
3-{(S)-2-[(S)-2-((S)-5-Guanidino-2-{(S)-3-(4-hydroxy-phenyl)-2-[(S)-2-(2-methanesulfonyl-ethoxycarbonylamino)-4-methyl-pentanoylamino]-propionylamino}-pentanoylamino)-propionylamino]-4-methyl-pentanoylsulfanyl}-propionic acid ethyl ester

: C₆₃H₉₄N₁₄O₁₇S

: C₆₃H₉₄N₁₄O₁₇S

Guidance literature:: 3-{(S)-2-[(S)-2-((S)-5-Guanidino-2-{(S)-3-(4-hydroxy-phenyl)-2-[(S)-2-(2-methanesulfonyl-ethoxycarbonylamino)-4-methyl-pentanoylamino]-propionylamino}-pentanoylamino)-propionylamino]-4-methyl-pentanoylsulfanyl}-propionic acid ethyl ester; H-Phe-Tyr(Ot-Bu)-Gly-Lys(Boc)-Ala-Rink-amide-ChampionsI resin; With 2,4,6-trimethyl-pyridine; sodium thiophenolate; copper(l) chloride; In N,N-dimethyl-formamide; at 45 ℃; for 16h;

With chlorotriisopropylsilane; water; trifluoroacetic acid; at 21 ℃; for 2h;
DOI:10.1021/ol035742m

Reference yield: 75.0%

: H-Phe-Tyr-Gly-Ser-Ala-NH₂

: 640266-23-5
3-{(S)-2-[(S)-2-((S)-5-Guanidino-2-{(S)-3-(4-hydroxy-phenyl)-2-[(S)-2-(2-methanesulfonyl-ethoxycarbonylamino)-4-methyl-pentanoylamino]-propionylamino}-pentanoylamino)-propionylamino]-4-methyl-pentanoylsulfanyl}-propionic acid ethyl ester

: C₆₀H₈₇N₁₃O₁₈S

: C₆₀H₈₇N₁₃O₁₈S

Guidance literature:: With 2,4,6-trimethyl-pyridine; N-hydroxybenzotriazole copper salt; In N,N-dimethyl-formamide; at 45 ℃; for 24h;
DOI:10.1021/ol035742m