2-(3-triisopropylsilanyloxymethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid amide

Base Information

• Chemical Name: 2-(3-triisopropylsilanyloxymethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid amide
• CAS No.: 313279-18-4
• Molecular Formula: C₂₄H₃₃N₃O₂Si
• Molecular Weight: 423.63
• Mol file: 313279-18-4.mol

Synonyms:2-(3-triisopropylsilanyloxymethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid amide

Chemical Property of 2-(3-triisopropylsilanyloxymethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-triisopropylsilanyloxymethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid amide

There total 8 articles about 2-(3-triisopropylsilanyloxymethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-nitroanthranilic acid (606-18-8) → 2-(3-triisopropylsilanyloxymethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid amide (313279-18-4)

Guidance literature:

Multi-step reaction with 4 steps

1: SOCl₂ / tetrahydrofuran; dimethylformamide / 20 °C

2: conc. aq. NH₃ / tetrahydrofuran; dimethylformamide

3: H₂ / 10percent Pd/C / methanol / 760.05 Torr

4: Cu(OAc)2 / methanol; H₂O / Heating

With ammonium hydroxide; thionyl chloride; copper diacetate; hydrogen; 10percent Pd/C; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm000950v

Reference yield:

2-amino-3-nitro-benzamide (313279-12-8) → 2-(3-triisopropylsilanyloxymethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid amide (313279-18-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol / 760.05 Torr

2: Cu(OAc)2 / methanol; H₂O / Heating

With copper diacetate; hydrogen; 10percent Pd/C; In methanol; water;

DOI:10.1021/jm000950v

Reference yield:

2-carbamoyl-3-nitrobenzoic acid (77326-45-5) → 2-(3-triisopropylsilanyloxymethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid amide (313279-18-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 93 percent / Br₂; aq. KOH / 3 h / 60 °C

2: SOCl₂ / tetrahydrofuran; dimethylformamide / 20 °C

3: conc. aq. NH₃ / tetrahydrofuran; dimethylformamide

4: H₂ / 10percent Pd/C / methanol / 760.05 Torr

5: Cu(OAc)2 / methanol; H₂O / Heating

With potassium hydroxide; ammonium hydroxide; thionyl chloride; copper diacetate; hydrogen; bromine; 10percent Pd/C; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm000950v

upstream raw materials:

2,3-diaminobenzamide

3-((triisopropylsilyloxy)methyl)benzaldehyde

1,3-dimethanol benzene

triisopropylsilyl chloride

Downstream raw materials:

2-(3-hydroxymethyl-phenyl)-1H-benzoimidazole-4-carboxylic acid amide