2-fluoro-N-[2-(4-methylpiperazin-1-yl)ethyl]-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]benzamide

Base Information

Chemical Name:2-fluoro-N-[2-(4-methylpiperazin-1-yl)ethyl]-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]benzamide
CAS No.:1073655-62-5
Molecular Formula:C₂₂H₂₉FN₆O₂
Molecular Weight:428.51
Hs Code.:

Synonyms:2-fluoro-N-[2-(4-methylpiperazin-1-yl)ethyl]-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]benzamide

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Chemical Property of 2-fluoro-N-[2-(4-methylpiperazin-1-yl)ethyl]-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]benzamide

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Technology Process of 2-fluoro-N-[2-(4-methylpiperazin-1-yl)ethyl]-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]benzamide

There total 5 articles about 2-fluoro-N-[2-(4-methylpiperazin-1-yl)ethyl]-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 934-98-5
2-(4-methylpiperazin-1-yl)ethylamine

: 1036403-32-3
2-fluoro-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]benzoic acid

: 1073655-62-5
2-fluoro-N-[2-(4-methylpiperazin-1-yl)ethyl]-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2012.06.021

Reference yield:

: 1036403-28-7
methyl 2-fluoro-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]benzoate

: 1073655-62-5
2-fluoro-N-[2-(4-methylpiperazin-1-yl)ethyl]-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 50 °C / Inert atmosphere

1.2: 20 °C / pH 4 / Inert atmosphere

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.06.021

Reference yield:

: 1036402-39-7
8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one

: 1073655-62-5
2-fluoro-N-[2-(4-methylpiperazin-1-yl)ethyl]-5-[(5-oxo-1,2,3,4,5,6-hexahydropyrido[2,3-d]pyridazin-8-yl)methyl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / N,N-dimethyl-formamide / 5 h / 100 °C / 3102.97 Torr / Inert atmosphere

2.1: platinum on carbon; hydrogen; acetic acid / 32 h / 20 °C / 1551.49 Torr / Inert atmosphere

3.1: lithium hydroxide / tetrahydrofuran; water / 50 °C / Inert atmosphere

3.2: 20 °C / pH 4 / Inert atmosphere

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; platinum on carbon; hydrogen; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.06.021