2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyryl amide

Base Information

Chemical Name:2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyryl amide
CAS No.:252022-36-9
Molecular Formula:C₁₆H₂₂ClNO₃
Molecular Weight:311.809
Hs Code.:

Synonyms:2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyryl amide

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Chemical Property of 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyryl amide

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Technology Process of 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyryl amide

There total 9 articles about 2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyryl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-{4-[2-(3-chloro-propyl)-[1,3]dioxolan-2-yl]-phenyl}-2-methyl-propionyl chloride

: 252022-36-9
2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyryl amide

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1016/S0014-827X(99)00070-1

Reference yield:

: 826-55-1
2-methyl-2-phenylpropionic acid

: 252022-36-9
2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyryl amide

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / LiAlH₄ / diethyl ether

2: 97 percent / Et₃N; 4-pyrrolidinopyridine / 0.33 h / 20 °C

3: 63.5 percent / AlCl₃ / CS₂ / 1.5 h / 0 - 5 °C

4: 68 percent / p-TsOH*H₂O / benzene / 24 h / Heating

5: 99 percent / NaOH; MeOH / 0.5 h / 20 °C

6: 89 percent / Jones reagent / acetone / 0 °C

7: (COCl)2 / 2.5 h / 20 °C

8: NH₄OH / tetrahydrofuran / 0.5 h / 0 °C

With methanol; ammonium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; jones reagent; oxalyl dichloride; 4-pyrrolidin-1-ylpyridine; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; carbon disulfide; diethyl ether; acetone; benzene; 1: Reduction / 2: Acetylation / 3: Acylation / 4: acetalisation / 5: deacetylation / 6: Oxidation / 7: Substitution / 8: Hydrolysis;
DOI:10.1016/S0014-827X(99)00070-1

Reference yield:

: 2173-69-5
2-methyl-2-phenyl-propan-1-ol

: 252022-36-9
2-[4-(1-Ethylendioxo-4-chlorobutyl)phenyl]isobutyryl amide

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / Et₃N; 4-pyrrolidinopyridine / 0.33 h / 20 °C

2: 63.5 percent / AlCl₃ / CS₂ / 1.5 h / 0 - 5 °C

3: 68 percent / p-TsOH*H₂O / benzene / 24 h / Heating

4: 99 percent / NaOH; MeOH / 0.5 h / 20 °C

5: 89 percent / Jones reagent / acetone / 0 °C

6: (COCl)2 / 2.5 h / 20 °C

7: NH₄OH / tetrahydrofuran / 0.5 h / 0 °C

With methanol; ammonium hydroxide; sodium hydroxide; aluminium trichloride; jones reagent; oxalyl dichloride; 4-pyrrolidin-1-ylpyridine; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; carbon disulfide; acetone; benzene; 1: Acetylation / 2: Acylation / 3: acetalisation / 4: deacetylation / 5: Oxidation / 6: Substitution / 7: Hydrolysis;
DOI:10.1016/S0014-827X(99)00070-1