3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanenitrile

Base Information

Chemical Name:3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanenitrile
CAS No.:439803-80-2
Molecular Formula:C₂₆H₂₆N₂O₂
Molecular Weight:398.505
Hs Code.:

Synonyms:3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanenitrile

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Chemical Property of 3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanenitrile

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Technology Process of 3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanenitrile

There total 11 articles about 3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanamide

: 439803-80-2
3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanenitrile

Guidance literature:: With pyridine; trifluoroacetic acid; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

: 439803-30-2
3-(5-methoxy-3,4-dihydronaphthalen-1-yl)propanoic acid

: 439803-80-2
3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanenitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine hydrochloride / 3 h / 180 °C

2.1: thionyl chloride / 0.33 h / -10 °C

2.2: 1 h / -10 - 20 °C

3.1: triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine / dichloromethane / 3 h / 20 °C

4.1: methanol; sodium hydroxide; water / tetrahydrofuran / 20 °C

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C

6.1: ammonia / tetrahydrofuran; water / 0.5 h

7.1: pyridine; trifluoroacetic acid / 1,4-dioxane / 1 h / 20 °C

With pyridine; methanol; sodium hydroxide; thionyl chloride; oxalyl dichloride; ammonia; water; pyridine hydrochloride; triphenylphosphine; trifluoroacetic acid; 1,1'-azodicarbonyl-dipiperidine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 157169-71-6
2-[5-methyl-2-(4-methylphenyl)-1,3-oxazol-4-yl]ethanol

: 439803-80-2
3-(5-(2-(2-(4-methylphenyl)-5-methyloxazol-4-yl)ethoxy)-3,4-dihydronaphthalen-1-yl)propanenitrile

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine / dichloromethane / 3 h / 20 °C

2: methanol; sodium hydroxide; water / tetrahydrofuran / 20 °C

3: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C

4: ammonia / tetrahydrofuran; water / 0.5 h

5: pyridine; trifluoroacetic acid / 1,4-dioxane / 1 h / 20 °C

With pyridine; methanol; sodium hydroxide; oxalyl dichloride; ammonia; water; triphenylphosphine; trifluoroacetic acid; 1,1'-azodicarbonyl-dipiperidine; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;