ethyl 7-(6-cyclopropyl-2,3-di-p-tolyl-5H-pyrrolo[2,3-b]pyrazin-5-yl)heptanoate

Base Information

Chemical Name:ethyl 7-(6-cyclopropyl-2,3-di-p-tolyl-5H-pyrrolo[2,3-b]pyrazin-5-yl)heptanoate
CAS No.:1447769-86-9
Molecular Formula:C₃₂H₃₇N₃O₂
Molecular Weight:495.665
Hs Code.:

Synonyms:ethyl 7-(6-cyclopropyl-2,3-di-p-tolyl-5H-pyrrolo[2,3-b]pyrazin-5-yl)heptanoate

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Chemical Property of ethyl 7-(6-cyclopropyl-2,3-di-p-tolyl-5H-pyrrolo[2,3-b]pyrazin-5-yl)heptanoate

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Technology Process of ethyl 7-(6-cyclopropyl-2,3-di-p-tolyl-5H-pyrrolo[2,3-b]pyrazin-5-yl)heptanoate

There total 4 articles about ethyl 7-(6-cyclopropyl-2,3-di-p-tolyl-5H-pyrrolo[2,3-b]pyrazin-5-yl)heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29823-18-5
ethyl 7-bromoheptanoate

: 1447770-32-2
6-cyclopropyl-2,3-di-p-tolyl-5H-pyrrolo[2,3-b]pyrazine

: 1447769-86-9
ethyl 7-(6-cyclopropyl-2,3-di-p-tolyl-5H-pyrrolo[2,3-b]pyrazin-5-yl)heptanoate

Guidance literature:: 6-cyclopropyl-2,3-di-p-tolyl-5H-pyrrolo[2,3-b]pyrazine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h; Inert atmosphere;

ethyl 7-bromoheptanoate; In N,N-dimethyl-formamide; mineral oil; for 2h; Inert atmosphere;

Reference yield:

: 1447770-30-0
3-bromo-5,6-di-p-tolylpyrazin-2-amine

: 1447769-86-9
ethyl 7-(6-cyclopropyl-2,3-di-p-tolyl-5H-pyrrolo[2,3-b]pyrazin-5-yl)heptanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

2.1: potassium tert-butylate / tert-butyl alcohol / 6 h / Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

3.2: 2 h / Inert atmosphere

With copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium tert-butylate; sodium hydride; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;

Reference yield:

: 1174186-69-6
5,6-di-p-tolylpyrazin-2-amine

: 1447769-86-9
ethyl 7-(6-cyclopropyl-2,3-di-p-tolyl-5H-pyrrolo[2,3-b]pyrazin-5-yl)heptanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / dimethyl sulfoxide / 2 h / 20 °C

2.1: triethylamine; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

3.1: potassium tert-butylate / tert-butyl alcohol / 6 h / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Inert atmosphere

4.2: 2 h / Inert atmosphere

With N-Bromosuccinimide; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium tert-butylate; sodium hydride; triethylamine; In 1,4-dioxane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;