1-methyl-4-{4-[(4-nitroanilino)carbonyl]anilino}pyridinium chloride

Base Information

• Chemical Name: 1-methyl-4-{4-[(4-nitroanilino)carbonyl]anilino}pyridinium chloride
• CAS No.: 1020087-01-7
• Molecular Formula: C₁₉H₁₇N₄O₃*Cl
• Molecular Weight: 384.822
• Mol file: 1020087-01-7.mol

Synonyms:1-methyl-4-{4-[(4-nitroanilino)carbonyl]anilino}pyridinium chloride

Chemical Property of 1-methyl-4-{4-[(4-nitroanilino)carbonyl]anilino}pyridinium chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methyl-4-{4-[(4-nitroanilino)carbonyl]anilino}pyridinium chloride

There total 5 articles about 1-methyl-4-{4-[(4-nitroanilino)carbonyl]anilino}pyridinium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-(4-nitrophenyl)-4-(4-pyridinylamino)benzamide (32567-71-8) + methyl p-toluene sulfonate (80-48-8) → 1-methyl-4-{4-[(4-nitroanilino)carbonyl]anilino}pyridinium chloride (1020087-01-7)

Guidance literature:

N-(4-nitrophenyl)-4-(4-pyridinylamino)benzamide; methyl p-toluene sulfonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

With AGR 1-X₄resin 200-400 (chloride form);

DOI:10.1016/j.bmc.2013.03.033

Reference yield:

1-methyl-4-{4-[(4-nitroanilino)carbonyl]anilino}pyridinium tosylate (1020087-03-9) → 1-methyl-4-{4-[(4-nitroanilino)carbonyl]anilino}pyridinium chloride (1020087-01-7)

Guidance literature:

With AG ^R 1-X₄ resin 200-400 chloride form; In methanol; water;

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 1-methyl-4-{4-[(4-nitroanilino)carbonyl]anilino}pyridinium chloride (1020087-01-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid; phenol / 1-methyl-pyrrolidin-2-one / 2.5 h / 110 - 180 °C

2.1: thionyl chloride / N,N-dimethyl-formamide / 1 h / Reflux

2.2: 1.33 h / 20 °C / Reflux

3.1: N,N-dimethyl-formamide / 18 h / 20 °C

3.2: AGR 1-X₄resin 200-400 (chloride form)

With thionyl chloride; toluene-4-sulfonic acid; phenol; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2013.03.033

upstream raw materials:

1-methyl-4-{4-[(4-nitroanilino)carbonyl]anilino}pyridinium tosylate

4-amino-benzoic acid

4-(p-(carboxyphenyl)amino)pyridine

N-(4-nitrophenyl)-4-(4-pyridinylamino)benzamide

Downstream raw materials:

4-{4-[(4-aminoanilino)carbonyl]anilino}-1-methylpyridinium chloride