methyl 4-amino-5-fluoro-6-(3-fluoro-4-(trimethylsilyl)phenyl)-3-methoxypicolinate

Base Information

Chemical Name:methyl 4-amino-5-fluoro-6-(3-fluoro-4-(trimethylsilyl)phenyl)-3-methoxypicolinate
CAS No.:1417331-29-3
Molecular Formula:C₁₇H₂₀F₂N₂O₃Si
Molecular Weight:366.44
Hs Code.:

Synonyms:methyl 4-amino-5-fluoro-6-(3-fluoro-4-(trimethylsilyl)phenyl)-3-methoxypicolinate

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Chemical Property of methyl 4-amino-5-fluoro-6-(3-fluoro-4-(trimethylsilyl)phenyl)-3-methoxypicolinate

Chemical Property:

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Technology Process of methyl 4-amino-5-fluoro-6-(3-fluoro-4-(trimethylsilyl)phenyl)-3-methoxypicolinate

There total 12 articles about methyl 4-amino-5-fluoro-6-(3-fluoro-4-(trimethylsilyl)phenyl)-3-methoxypicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1417331-25-9
methyl 4-amino-6-chloro-5-fluoro-3-methoxypicolinate

: 1417332-32-1
(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)trimethylsilane

: 1417331-29-3
methyl 4-amino-5-fluoro-6-(3-fluoro-4-(trimethylsilyl)phenyl)-3-methoxypicolinate

Guidance literature:: With potassium fluoride; bis-triphenylphosphine-palladium(II) chloride; In water; acetonitrile; at 115 ℃; for 0.333333h; microwave irradiation; Sealed tube;

Reference yield:

: 1435-52-5
2,5-dibromofluorobenzene

: 1417331-29-3
methyl 4-amino-5-fluoro-6-(3-fluoro-4-(trimethylsilyl)phenyl)-3-methoxypicolinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; diethyl ether / 2 h / -78 °C

1.2: 72 h / -78 - 23 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C

2.2: 20 h / -78 - 23 °C

3.1: potassium fluoride / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 0.33 h / 115 °C / microwave irradiation; Sealed tube

With potassium fluoride; n-butyllithium; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; diethyl ether; hexane; water; acetonitrile;

Reference yield:

: 1388157-64-9
isopropyl 4-amino-5,6-difluoropicolinate

: 1417331-29-3
methyl 4-amino-5-fluoro-6-(3-fluoro-4-(trimethylsilyl)phenyl)-3-methoxypicolinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 1,4-dioxane / 20 - 100 °C

2.1: titanium(IV) isopropylate / 4 h / Reflux

3.1: iodine; periodic acid / methanol / 20 h / Reflux

4.1: caesium carbonate / 1,10-Phenanthroline; copper(l) iodide / methanol / 65 °C / Inert atmosphere

4.2: pH 2

5.1: hydrogenchloride / 4 h / 50 °C

6.1: potassium fluoride / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 0.33 h / 115 °C / microwave irradiation; Sealed tube

With titanium(IV) isopropylate; hydrogenchloride; potassium fluoride; iodine; caesium carbonate; periodic acid; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 1,10-Phenanthroline; In 1,4-dioxane; methanol; water; acetonitrile;