4-methyl-N-(4-methyl-2-(naphthalen-1-yl)phenyl)benzenesulfonamide

Base Information

• Chemical Name: 4-methyl-N-(4-methyl-2-(naphthalen-1-yl)phenyl)benzenesulfonamide
• CAS No.: 1426812-93-2
• Molecular Formula: C₂₄H₂₁NO₂S
• Molecular Weight: 387.502
• Mol file: 1426812-93-2.mol

Synonyms:4-methyl-N-(4-methyl-2-(naphthalen-1-yl)phenyl)benzenesulfonamide

Chemical Property of 4-methyl-N-(4-methyl-2-(naphthalen-1-yl)phenyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-N-(4-methyl-2-(naphthalen-1-yl)phenyl)benzenesulfonamide

There total 4 articles about 4-methyl-N-(4-methyl-2-(naphthalen-1-yl)phenyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-methyl-2-(naphthalen-1-yl)aniline (1183962-77-7) + p-toluenesulfonyl chloride (98-59-9) → 4-methyl-N-(4-methyl-2-(naphthalen-1-yl)phenyl)benzenesulfonamide (1426812-93-2)

Guidance literature:

With pyridine; at 120 ℃; for 2h;

DOI:10.1002/adsc.201200314

Reference yield:

2-bromo-p-toluidine (583-68-6) → 4-methyl-N-(4-methyl-2-(naphthalen-1-yl)phenyl)benzenesulfonamide (1426812-93-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 24 h / 80 °C / Inert atmosphere

2: pyridine / 2 h / 120 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In water; N,N-dimethyl-formamide;

DOI:10.1021/ol4001922

Reference yield:

1-Naphthylboronic acid (13922-41-3) → 4-methyl-N-(4-methyl-2-(naphthalen-1-yl)phenyl)benzenesulfonamide (1426812-93-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 24 h / 80 °C / Inert atmosphere

2: pyridine / 2 h / 120 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In water; N,N-dimethyl-formamide;

DOI:10.1021/ol4001922

upstream raw materials:

2-bromo-p-toluidine

1-Naphthylboronic acid

4-methyl-2-(naphthalen-1-yl)aniline

p-toluenesulfonyl chloride

Downstream raw materials:

2-methyl-5-tosylbenzo[k]phenanthridin-6(5H)-one